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Invitrogen
Cyclopiazonic acid Recombinant Mouse Monoclonal Antibody (1C10)
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FIGURE: 1 / 1
Cyclopiazonic acid Antibody (MA566560) in SDS-PAGE
SDS-PAGE characterization of Cyclopiazonic acid under reducing conditions. Lane M: Protein marker (kDa); Lane CPA: Purified Cyclopiazonic acid Recombinant Monoclonal (Product # MA566560). Cyclopiazonic acid showing heavy chain (~50 kDa) and light chain (~25 kDa). Gels were stained with Coomassie Brilliant Blue R-359.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
MA566560
Product Specifications
Species Reactivity
Chemical
Host/Isotype
Mouse
/ IgG
Expression System
CHO cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
1C10
Immunogen
Conjugate of CPA hapten and KLH.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
2 mg/mL
Amount
200 µg
Purification
Protein G
Storage buffer
PBS, pH 7.4
Contains
0.1% NeoCide PC-950
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Target Information
Cyclopiazonic acid (CPA) is a toxic indole tetramic acid produced by fungi such as Aspergillus and Penicillium species. It is known for its ability to inhibit calcium-dependent ATPases, specifically targeting the sarcoendoplasmic reticulum Ca2+-ATPase (SERCA), which disrupts calcium homeostasis within cells. This inhibition can lead to various toxic effects, including weight loss, muscle degeneration, convulsions, and potentially death in animals. CPA has been detected in various foods and feeds, posing a risk of acute mycotoxicoses in humans, with symptoms such as giddiness and nausea. Additionally, CPA has shown promising antiplasmoidal activities, comparable to chloroquine, and has been identified as an inhibitor of respiratory syncytial virus (RSV) in cell-based assays. Its neurotoxic effects have been studied in animal models, indicating potential depressive symptoms and neurocognitive impairments.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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