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Invitrogen
CD49a Recombinant Rabbit Monoclonal Antibody (2H9J4)
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FIGURE: 1 / 3
CD49a Antibody (MA569544) in ICC/IF
Immunocytochemical analysis of CD49a in Neuro-2a cells. Samples were incubated with CD49a recombinant monoclonal antibody (Product # MA569544) using a dilution of 1:200 (40x lens). Followed by a further incubation with Cy3 Goat Anti-Rabbit IgG (H+L) using a dilution of 1:500 (Red). The cells were counterstained with alpha-Tubulin Mouse mAb using dilution of 1:400. Followed by incubation with 488-conjugated Goat Anti-Mouse IgG (H+L) using a dilution of 1:500 (Green). DAPI was used for nuclear staining (Blue).
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
MA569544
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
2H9J4
Immunogen
Recombinant protein (or fragment).
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.3., with 50% glycerol, 0.05% BSA
Contains
0.09% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
Integrin alpha 1 (ITGA1) chain associates with the beta 1 (ITGB1) chain to form a heterodimer that functions as a dual laminin/collagen receptor in neural cells and hematopoietic cells. ITGA1 has a 206-amino acid I domain in its N-terminal half, followed by 3 divalent cation-binding sites and a C-terminal transmembrane domain with a short cytoplasmic tail. It also has 28 potential N-glycosylation sites. Human ITGA1 was expressed in a mouse fibroblast cell line as a 180-kD protein. ITGA1 is involved in the early remodeling of osteoarthritic cartilage and plays an essential role in the regulation of mesenchymal stem cell proliferation and cartilage production. It also plays an essential role in the regulation of MSC proliferation and cartilage production.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CD49 antigen-like family member A; laminin and collagen receptor; unnamed protein product; VLA-1
Gene Aliases: CD49A; E130012M19Rik; Vla1
UniProt ID: (Rat) P18614, (Mouse) Q3V3R4
Entrez Gene ID: (Rat) 25118, (Mouse) 109700
cell adhesion
cell-matrix adhesion
integrin-mediated signaling pathway
negative regulation of cell proliferation
neutrophil chemotaxis
negative regulation of epidermal growth factor receptor signaling pathway
vasodilation
positive regulation of MAPK cascade
positive regulation of neuron apoptotic process
cellular extravasation
neuron projection morphogenesis
cell chemotaxis
cell-cell adhesion
Disclaimer
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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