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Invitrogen

HO-1 Recombinant Rabbit Monoclonal Antibody (3P3P4)

View all (49) HO-1 antibodies

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Product Details

MA569716

Applications
Tested Dilution
Publications

Western Blot (WB)

1:2,000-1:10,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:10,000-1:40,000
-

ELISA (ELISA)

1 µg/mL
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Expression System

HEK293 cells

Class

Recombinant Monoclonal

Type

Antibody

Clone

3P3P4

Immunogen

Recombinant protein (or fragment).

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.3., with 50% glycerol, 0.05% BSA

Contains

0.09% sodium azide

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

Target Information

Heme oxygenase (HO) is a microsomal enzyme that catalyzes the oxidation of heme to the antioxidant molecules, biliverdin and carbon monoxide. HO consists of two homologous isozymes, an inducible HO-1 and a constitutively expressed HO-2. HO-1 is induced by a wide variety of stimuli including conditions of oxidative stress, inflammatory agents, transforming growth factor beta and heat shock. The increase in expression of HO-1 is thought to be a cellular defense mechanism against oxidative stress since elevated HO could eventually generate more bilirubin, an anti-oxidant.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: heat shock protein, 32-kD; heme orygenase 1; heme oxygenase (decycling) 1; heme oxygenase (decyclizing) 1; hemoxygenase; HMOX1; P32 protein; unnamed protein product

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Gene Aliases: bK286B10; D8Wsu38e; Hemox; Heox; HEOXG; Hmox; HMOX1D; HO-1; HO1; HSP32

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UniProt ID: (Human) P09601, (Rat) P06762, (Mouse) P14901

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Entrez Gene ID: (Human) 3162, (Rat) 24451, (Mouse) 15368

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Function(s)
heme oxygenase (decyclizing) activity structural molecule activity protein binding enzyme binding heme binding identical protein binding protein homodimerization activity phospholipase D activity arachidonic acid omega-hydroxylase activity
Process(es)
angiogenesis endothelial cell proliferation wound healing involved in inflammatory response negative regulation of leukocyte migration regulation of transcription from RNA polymerase II promoter heme oxidation cellular iron ion homeostasis response to oxidative stress smooth muscle hyperplasia positive regulation of chemokine production erythrocyte homeostasis low-density lipoprotein particle clearance cellular response to heat response to nicotine intracellular signal transduction heme catabolic process response to hydrogen peroxide positive regulation of I-kappaB kinase/NF-kappaB signaling regulation of angiogenesis positive regulation of angiogenesis positive regulation of smooth muscle cell proliferation negative regulation of smooth muscle cell proliferation multicellular organismal iron ion homeostasis positive regulation of cell migration involved in sprouting angiogenesis negative regulation of ferroptosis negative regulation of cytokine production involved in inflammatory response negative regulation of extrinsic apoptotic signaling pathway via death domain receptors positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis response to hypoxia phospholipid metabolic process small GTPase mediated signal transduction regulation of blood pressure negative regulation of cell proliferation intrinsic apoptotic signaling pathway in response to DNA damage response to xenobiotic stimulus negative regulation of muscle cell apoptotic process positive regulation of macroautophagy negative regulation of macroautophagy cellular response to nutrient negative regulation of mast cell cytokine production heme metabolic process positive regulation of apoptotic process negative regulation of mast cell degranulation negative regulation of neuron apoptotic process response to estrogen negative regulation by host of viral transcription cellular response to arsenic-containing substance cellular response to cadmium ion cellular response to cisplatin liver regeneration negative regulation of viral life cycle negative regulation of epithelial cell apoptotic process response to arachidonate response to 3-methylcholanthrene negative regulation of vascular smooth muscle cell proliferation
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