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Invitrogen

Bcl-10 Recombinant Rabbit Monoclonal Antibody (PSH13-49)

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Bcl-10 Recombinant Rabbit Monoclonal Antibody (PSH13-49)

Product Details

MA570007

Applications
Tested Dilution
Publications

Western Blot (WB)

1:50,000
-

Immunocytochemistry (ICC/IF)

1:100
-

Flow Cytometry (Flow)

1:1,000
-

Immunoprecipitation (IP)

1-2 µg
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Expression System

HEK293 cells

Class

Recombinant Monoclonal

Type

Antibody

Clone

PSH13-49

Immunogen

Recombinant protein within human Bcl10 aa 1-233.
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

Protein A

Storage buffer

PBS, pH 7.4, with 0.1% BSA, 40% glycerol

Contains

0.05% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

Product Specific Information

Positive control: A20 cell lysate, RAW264.7 cell lysate, EL4 cell lysate, CTLL-2 cell lysate, Ramos cell lysate, Rat brain tissue lysate, Raji.

Subcellular location: Cytoplasm, perinuclear region, Membrane raft.

Target Information

BCL-10 is an N-terminal CARD (Caspase Recruitment Domain) containing protein that is involved in the adaptive immune response. It promotes apoptosis, pro-caspase-9 maturation, and activation of NF-kappa-B via NIK and IKK. BCL-10 is also an adapter protein between upstream TNFR1-TRADD-RIP complex and the downstream NIK-IKK-IKAP complex. It is a substrate for MALT1. Mutations in the gene can lead to Immmunodeficiency 37 or Lymphoma, mucosa-associated lymphoid type.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: B cell CLL/lymphoma 10; B-cell CLL/lymphoma 10; B-cell leukemia/lymphoma 10; bcl-10; CARD containing molecule enhancing NF-kB; CARD-containing apoptotic signaling protein; CARD-containing molecule enhancing NF-kappa-B; CARD-containing proapoptotic protein; CARD-like apoptotic protein; CARMEN; caspase-recruiting domain-containing protein; cCARMEN; CED-3/ICH-1 prodomain homologous E10-like regulator; cellular homolog of vCARMEN; cellular-E10; hCLAP; Mamm; mammalian CARD-containing adapter molecule E10; OTTHUMP00000011647; OTTHUMP00000036080; protein binding; signal transducer activity; R-RCD1; RCD; RP11-234D19.2; unnamed protein product

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Gene Aliases: BCL-10; c-E10; CARMEN; cE10; CIPER; CLAP; IMD37; ME10

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UniProt ID: (Human) O95999, (Mouse) Q9Z0H7, (Rat) Q9QYN5

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Entrez Gene ID: (Human) 8915, (Mouse) 12042, (Rat) 83477

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Function(s)
protease binding transcription coactivator activity protein binding kinase activator activity protein binding, bridging ubiquitin protein ligase binding signaling adaptor activity identical protein binding protein kinase B binding macromolecular complex binding CARD domain binding NF-kappaB binding general transcription initiation factor binding cysteine-type endopeptidase activator activity involved in apoptotic process protein homodimerization activity protein heterodimerization activity
Process(es)
positive regulation of cytokine production neural tube closure toll-like receptor signaling pathway adaptive immune response negative regulation of mature B cell apoptotic process apoptotic process programmed cell death positive regulation of protein ubiquitination lipopolysaccharide-mediated signaling pathway response to food response to lipopolysaccharide positive regulation of interleukin-6 production positive regulation of interleukin-8 production positive regulation of lymphotoxin A production positive regulation of mast cell cytokine production NIK/NF-kappaB signaling regulation of apoptotic process positive regulation of apoptotic process regulation of I-kappaB kinase/NF-kappaB signaling positive regulation of I-kappaB kinase/NF-kappaB signaling innate immune response positive regulation of transcription, DNA-templated T cell receptor signaling pathway positive regulation of T cell receptor signaling pathway protein homooligomerization antifungal innate immune response cellular response to lipopolysaccharide cellular response to mechanical stimulus apoptotic signaling pathway positive regulation of extrinsic apoptotic signaling pathway B cell apoptotic process cellular defense response response to fungus immunoglobulin mediated immune response positive regulation of phosphorylation mast cell activation regulation of T cell receptor signaling pathway positive regulation of T cell activation T cell apoptotic process positive regulation of execution phase of apoptosis
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