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Invitrogen

RXRB Recombinant Rabbit Monoclonal Antibody (PSH13-53)

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RXRB Recombinant Rabbit Monoclonal Antibody (PSH13-53)

Product Details

MA571373

Applications
Tested Dilution
Publications

Western Blot (WB)

1:5,000
-

Multiplex Immunohistochemistry (mIHC)

1:100
-

Immunohistochemistry (Paraffin) (IHC (P))

1:200-1:1,000
-

Immunocytochemistry (ICC/IF)

1:100
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Expression System

HEK293 cells

Class

Recombinant Monoclonal

Type

Antibody

Clone

PSH13-53

Immunogen

Recombinant protein within human aa 1-250.
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

Protein A

Storage buffer

PBS, pH 7.4, with 0.1% BSA, 40% glycerol

Contains

0.05% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

Product Specific Information

Positive Control: SH-SY5Y cell lysate, K-562 cell lysate, MDA-MB-231 cell lysate, U-2 OS cell lysate, NIH/3T3 cell lysate, Mouse brain tissue lysate, Rat brain tissue lysate, SH-SY5Y, NIH/3T3, human brain tissue, human lung tissue, mouse brain tissue, rat brain tissue, rat lung tissue.

Tissue Specificity: Low tissue specificity

Subcellular Location: Nucleus, Cytoplasm.

Sequence Similarities: 90% Mouse/Rat

Predicted band size: 57 kDa

Target Information

This gene encodes a member of the retinoid X receptor (RXR) family of nuclear receptors which are involved in mediating the effects of retinoic acid (RA). This receptor forms homodimers with the retinoic acid, thyroid hormone, and vitamin D receptors, increasing both DNA binding and transcriptional function on their respective response elements. The gene lies within the major histocompatibility complex (MHC) class II region on chromosome 6.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: DADB-100D22.1; MGC1831; MHC class I promoter binding protein; MHC class I regulatory element binding protein (H-2RIIBP); MHC class I regulatory element-binding protein H-2RIIBP; nuclear receptor co-regulator 1; nuclear receptor coregulator 1; nuclear receptor subfamily 2 group B member 2; putative new variant; putative retinoid X receptor beta; retinoic acid receptor, beta; retinoid X receptor; RXR Beta; unnamed protein product

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Gene Aliases: DAUDI6; H-2RIIBP; NR2B2; RCoR-1; Rub; RXR-beta; RXRbeta

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UniProt ID: (Human) P28702, (Mouse) P28704

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Entrez Gene ID: (Human) 6257, (Mouse) 20182, (Rat) 361801

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Function(s)
transcription regulatory region sequence-specific DNA binding RNA polymerase II regulatory region sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding DNA binding transcription factor activity, sequence-specific DNA binding steroid hormone receptor activity RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding protein binding zinc ion binding chromatin DNA binding sequence-specific DNA binding retinoic acid-responsive element binding sequence-specific double-stranded DNA binding RNA polymerase II core promoter proximal region sequence-specific DNA binding identical protein binding vitamin D receptor binding retinoic acid receptor binding macromolecular complex binding thyroid hormone receptor binding
Process(es)
in utero embryonic development maternal placenta development regulation of transcription, DNA-templated nervous system development hormone-mediated signaling pathway cell differentiation positive regulation of bone mineralization intracellular steroid hormone receptor signaling pathway regulation of myelination mRNA transcription from RNA polymerase II promoter positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter retinoic acid receptor signaling pathway ventricular cardiac muscle cell differentiation cardiac muscle cell proliferation positive regulation of vitamin D receptor signaling pathway cellular response to retinoic acid nuclear receptor-mediated signaling pathway
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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