Identification of epithelial ovarian tumor-specific aptamers.
AuthorsBenedetto G, Hamp TJ, Wesselman PJ, Richardson C
Journal
PubMed ID25894736
'Ovarian cancer is often diagnosed in late stages with few treatment options and poor long-term prognosis. New clinical tools for early detection of ovarian malignancies will significantly help reduce mortality and improve current long-term survival rates. The objective of this work was to identify ovarian tumor-specific single-stranded DNA aptamers that ... More
Scavenger receptor-recognized and enzyme-responsive nanoprobe for fluorescent labeling of lysosomes in live cells.
AuthorsFan Y, Li F, Chen D,
Journal
PubMed ID24929616
Lysosomal imaging represents a potent tool for investigating the organization of related cellular events and their modulation via diagnostic and therapeutic approaches. However, specific labeling of the lysosome in live cells is a significant challenge. Taking advantage of the inherent lysosomal entry of nanoparticles and unique digestive inclusions in the ... More
Synthesis and Biological Characterization of a New Norbormide Derived Bodipy FL-Conjugated Fluorescent Probe for Cell Imaging.
Authors
JournalFront Pharmacol
PubMed ID30319407
Systematic mapping of genetic interactions for de novo fatty acid synthesis identifies C12orf49 as a regulator of lipid metabolism.
Authors
JournalNat Metab
PubMed ID32694731
LY6E mediates an evolutionarily conserved enhancement of virus infection by targeting a late entry step.
Authors
JournalNat Commun
PubMed ID30190477
A dynamic formin-dependent deep F-actin network in axons.
Authors
JournalJ Cell Biol
PubMed ID26216902
Structural and Functional Characterization of Fibronectin in Extracellular Vesicles From Hepatocytes.
Authors
JournalFront Cell Dev Biol
PubMed ID33816490
The Establishment and Application Studies on Precise Lysosome pH Indicator Based on Self-Decomposable Nanoparticles.
Authors
JournalNanoscale Res Lett
PubMed ID32642882
The Transferrin Receptor CD71 Delineates Functionally Distinct Airway Macrophage Subsets during Idiopathic Pulmonary Fibrosis.
Authors
JournalAm J Respir Crit Care Med
PubMed ID31051082
Loss-of-function mutations in ATP6AP1 and ATP6AP2 in granular cell tumors.
AuthorsPareja F, Brandes AH, Basili T, Selenica P, Geyer FC, Fan D, Da Cruz Paula A, Kumar R, Brown DN, Gularte-Mérida R, Alemar B, Bi R, Lim RS, de Bruijn I, Fujisawa S, Gardner R, Feng E, Li A, da Silva EM, Lozada JR, Blecua P, Cohen-Gould L, Jungbluth AA, Rakha EA, Ellis IO, Edelweiss MIA, Palazzo J, Norton L, Hollmann T, Edelweiss M, Rubin BP, Weigelt B, Reis-Filho JS
JournalNat Commun
PubMed ID30166553
Granular cell tumors (GCTs) are rare tumors that can arise in multiple anatomical locations, and are characterized by abundant intracytoplasmic granules. The genetic drivers of GCTs are currently unknown. Here, we apply whole-exome sequencing and targeted sequencing analysis to reveal mutually exclusive, clonal, inactivating somatic mutations in the endosomal pH ... More