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Invitrogen
ATG4B Polyclonal Antibody
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Product Details
PA1-18295
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthetic peptide (CLERFFDSEDED) corresponding to the C-terminus of human ATG4B protein (aa 377-387).
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Lyophilized
Concentration
Conc. Not Determined
Storage buffer
whole serum
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material. After reconstitution keep aliquots at -20 °C for a higher stability, and at 4 °C with an appropriate antibacterial agent. Glycerol (1:1) may be added for an additional stability. Avoid repetitive freeze/thaw cycles.
Target Information
Cysteine protease ATG4b is an enzyme which is coded by ATG4b gene. Autophagy is a critical cellular homeostatic process that controls the turnover of damaged organelles and protein. ATG4b is a deubiquitin-like protease that plays dual roles in the core machinery of autophagy. ATG4b, cleaves the C-terminal amino acid of ATG8 family proteins MAP1LC3, GABARAPL1, GABARAPL2 and GABARAP, to reveal a C-terminal glycine. Exposure of the glycine at the C-terminus is essential for ATG8 proteins conjugation to phosphatidylethanolamine (PE) and insertion to membranes, which is necessary for autophagy. ATG4b is mainly expressed in the skeletal muscle, brain, heart, liver and pancreas.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: APG4 autophagy 4 homolog B; ATG4 autophagy related 4 homolog B; AUT-like 1 cysteine; AUT-like 1 cysteine endopeptidase; autophagin-1; autophagy related 4 homolog B; autophagy-related 4B; autophagy-related cysteine endopeptidase 1; autophagy-related protein 4 homolog B; hAPG4B; unnamed protein product
Gene Aliases: APG4B; AUTL1; HsAPG4B
UniProt ID: (Human) Q9Y4P1, (Rat) A0A0G2QC33
Entrez Gene ID: (Human) 23192, (Rat) 316640
autophagosome assembly
mitophagy
proteolysis
autophagy
macroautophagy
lysosomal microautophagy
protein processing
otolith mineralization completed early in development
protein localization to pre-autophagosomal structure
piecemeal microautophagy of nucleus
aggrephagy
protein delipidation
cellular response to starvation
positive regulation of protein catabolic process
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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