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Invitrogen
Dopamine beta Hydroxylase Polyclonal Antibody
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Dopamine beta Hydroxylase Antibody (PA1-18314) in IHC
International journal of molecular sciences 2024 -
Confirmation of the chemogenetic technique by immunohistochemistry 6 weeks after injection of rAAV8/hSyn-DIO-mCherry (Addgene #50459) into the median raphe region (MRR) of dopamine transporter Cre (DAT-Cre) mice. Subregions (MRR and PMR/paramedian raphe/) are defined based on the Mouse Brain Atlas []. Position of the coronal section is indicated in each image, relative to the Bregma. ( a ) Fluorescent micro... View More
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA1-18314
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Bovine,
Guinea pig,
Human,
Rat
Published species
Mouse,
Sheep
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Native enzyme prepared from bovine adrenal glands.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Lyophilized
Concentration
Conc. Not Determined
Storage buffer
whole serum
Contains
no preservative
Storage conditions
4°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material. Store lyophilized antibody at 2-8 °C. After reconstitution keep aliquots at -20 °C for a higher stability, and at 4 °C with an appropriate antibacterial agent. Avoid repetitive freeze/thaw cycles. Glycerol (1:1) may be added for an additional stability.
Target Information
The protein encoded by this gene is an oxidoreductase belonging to the copper type II, ascorbate-dependent monooxygenase family. It is present in the synaptic vesicles of postganglionic sympathetic neurons and converts dopamine to norepinephrine. It exists in both soluble and membrane-bound forms, depending on the absence or presence, respectively, of a signal peptide.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Dopamine beta hydroxylase (dopamine beta-monooxygenase); dopamine beta-hydroxylase (dopamine beta-monooxygenase); dopamine beta-hydroxylase precursor (EC 1.14.17.1); dopamine beta-monooxygenase; dopamine beta-monooxygenase precursor (EC 1.14.17.1); Dopamine-Beta-hydroxylase; mixed function oxidase; unnamed protein product
Gene Aliases: DBM; DOPBHY; ORTHYP1
UniProt ID: (Bovine) P15101, (Human) P09172, (Rat) Q05754
Entrez Gene ID: (Bovine) 280758, (Human) 1621, (Guinea pig) 100727873, (Rat) 25699
dopamine beta-monooxygenase activity
copper ion binding
L-ascorbic acid binding
catalytic activity
monooxygenase activity
protein binding
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen
hydroxylase
oxidoreductase
metabolite interconversion enzyme
dopamine catabolic process
norepinephrine biosynthetic process
oxidation-reduction process
chemical synaptic transmission
behavioral response to ethanol
positive regulation of cold-induced thermogenesis
blood vessel remodeling
response to amphetamine
leukocyte mediated immunity
catecholamine metabolic process
memory
locomotory behavior
associative learning
visual learning
response to xenobiotic stimulus
response to iron ion
response to ozone
response to estradiol
social behavior
response to isolation stress
response to immobilization stress
regulation of cell proliferation
homoiothermy
glucose homeostasis
fear response
maternal behavior
response to peptide hormone
response to ethanol
positive regulation of vasoconstriction
octopamine metabolic process
response to copper ion
response to pain
leukocyte migration
bone development
cellular response to manganese ion
cellular response to nicotine
regulation of extrinsic apoptotic signaling pathway
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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