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Invitrogen

Tyrosine Hydroxylase Polyclonal Antibody

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View all (52) Tyrosine Hydroxylase antibodies

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Tyrosine Hydroxylase Polyclonal Antibody

Product Details

PA1-18315

Applications
Tested Dilution
Publications

Western Blot (WB)

1:1,000
-

Immunohistochemistry (IHC)

-
View 1 publication 1 publication

Immunohistochemistry (Frozen) (IHC (F))

1:2,000-1:5,000
-
Product Specifications

Species Reactivity

Guinea pig, Human, Mouse, Rat

Published species

Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Synthetic peptide corresponding to residues P (63) R F I G R R Q S L I E D A R K(78) of human Tyrosine Hydroxylase conjugated to KLH.
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Lyophilized

Concentration

Conc. Not Determined

Storage buffer

whole serum

Contains

no preservative

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_1088125

Product Specific Information

Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material. After reconstitution keep aliquots at -20 °C for a higher stability, and at 4 °C with an appropriate antibacterial agent. Glycerol (1:1) may be added for an additional stability. Avoid repetitive freeze/thaw cycles.

Target Information

Tyrosine hydroxylase (TH) is an enzyme involved in the synthesis of catecholamine neurotransmitters dopamine, epinephrine, and norepinephrine. In all species, catecholamine synthesis is regulated by the interaction of TH with a cofactor, tetrahydrobiopterin (BH4). BH4 binds to the TH catalytic domain, resulting in enzymatic activity. Unlike TH in non-primate species, four human TH mRNA splice variants (hTH1-hTH4) have been isolated. These variants are identical in their catalytic domain, but differ in their N-terminal, regulatory domains. TH is also responsible for the conversion of L-tyrosine to L-dopa. TH plays a key role in the physiology of adrenergic neurons. The role of TH in the synthesis of catecholamine neurotransmitters suggests a correlation between the enzyme and a number of neuropathogenic diseases including: Parkinson's disease, schizophrenia, Segawa syndrome, and dystonia, as well as a variety of cardiovascular diseases.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Bioinformatics

Protein Aliases: aromatic amino acid hydroxylase; dystonia 14; EC 1.14.16.2; HGNC:11782; TH isoform 3; TH isoform a; TH-4; TY3H; TYH antibody; tyrosine 3-hydroxylase; tyrosine hydroxylase (EC 1.14.16.2); tyrosine hydroxylase type 4 (EC 1.14.16.2); unnamed protein product

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Gene Aliases: DYT14; DYT5b; The; TYH

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UniProt ID: (Human) P07101, (Mouse) P24529, (Rat) P04177

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Entrez Gene ID: (Human) 7054, (Mouse) 21823, (Guinea pig) 100734150, (Rat) 25085

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Function(s)
monooxygenase activity tyrosine 3-monooxygenase activity iron ion binding protein binding oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen enzyme binding identical protein binding ferrous iron binding ferric iron binding amino acid binding oxygen binding protein domain specific binding tetrahydrobiopterin binding dopamine binding small molecule binding
Process(es)
response to hypoxia synaptic transmission, dopaminergic dopamine biosynthetic process from tyrosine heart development visual perception learning memory mating behavior locomotory behavior regulation of heart contraction aromatic amino acid family metabolic process organ morphogenesis aminergic neurotransmitter loading into synaptic vesicle dopamine biosynthetic process epinephrine biosynthetic process norepinephrine biosynthetic process catecholamine biosynthetic process eye photoreceptor cell development eating behavior response to leptin response to ethanol embryonic camera-type eye morphogenesis cognition hyaloid vascular plexus regression heart morphogenesis anatomical structure morphogenesis pigmentation response to amphetamine fatty acid metabolic process sphingolipid metabolic process response to xenobiotic stimulus response to light stimulus response to herbicide response to salt stress response to metal ion response to zinc ion response to activity response to insecticide phthalate metabolic process cerebral cortex development response to nutrient levels response to estradiol response to lipopolysaccharide response to nicotine social behavior response to isolation stress response to immobilization stress circadian sleep/wake cycle response to peptide hormone response to ether response to pyrethroid response to steroid hormone response to corticosterone response to electrical stimulus response to growth factor cellular response to manganese ion cellular response to alkaloid cellular response to nicotine cellular response to glucose stimulus cellular response to growth factor stimulus cellular response to xenobiotic stimulus response to curcumin
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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