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Invitrogen
Ghrelin Polyclonal Antibody
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Product Details
PA1-18413
Product Specifications
Species Reactivity
Human,
Sheep
Host/Isotype
Guinea pig
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide corresponding to the amino acids 24-51 from human ghrelin, conjugated to carrier protein.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Lyophilized
Concentration
Conc. Not Determined
Storage buffer
whole serum
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Reconstitute in 50 µL sterile water. Centrifuge to remove any insoluble material. It is recommended that a thawed sample is stored at 4 °C for no longer than 2 weeks. Allocation of appropriate anti-bacterial agent can increase shelf life by several weeks. Diluted serum should be prepared as required. Long term stability requires storage, preferably in small aliquots at -20 °C or lower. Glycerol (1:1) can be added to neat serum for additional stability if intended use does not prevent this.
Target Information
GHRL encodes ghrelin-obestatin preproprotein, which generates ghrelin and obestatin. Ghrelin is an the ligand for the growth hormone secretagogue receptor type 1 and is involved in regulating growth hormone release. Ghrelin has an appeptite-stimulating effect and induces adiposity and stimulates gastric acid secretion. Obestatin may be the ligand for the orphan G protein-coupled receptor GPR39 and is involved in satiety and can have an appetite-reducing effect resulting in decreased food intake.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: AMCBX1; appetite-regulating hormone isoform In2c; exon 2- and 3-deleted preproghrelin; exon 2-deleted preproghrelin; FIP-3; FIP3; Fip3p; ghrelin 27; ghrelin 28; ghrelin, growth hormone secretagogue receptor ligand; ghrelin/obestatin; ghrelin/obestatin preprohormone; ghrelin/obestatin prepropeptide; growth hormone-releasing peptide; IKK-gamma; In2c-preproghrelin; IP; IP1; IP2; IPD2; motilin-related peptide; NEMO; OTTHUMP00000207794; OTTHUMP00000207795; OTTHUMP00000207796; OTTHUMP00000207798; prepro-appetite regulatory hormone; preproghrelin
Gene Aliases: ghrelin; MTLRP
UniProt ID: (Human) Q9UBU3
Entrez Gene ID: (Human) 51738, (Sheep) 442996
gastric acid secretion
negative regulation of endothelial cell proliferation
glucose metabolic process
G-protein coupled receptor signaling pathway
positive regulation of cytosolic calcium ion concentration
actin polymerization or depolymerization
adult feeding behavior
response to hormone
hormone-mediated signaling pathway
dendrite development
negative regulation of angiogenesis
growth hormone secretion
response to nutrient levels
positive regulation of insulin secretion
regulation of response to food
positive regulation of response to food
positive regulation of appetite
negative regulation of interleukin-1 beta production
negative regulation of interleukin-6 production
negative regulation of tumor necrosis factor production
positive regulation of insulin secretion involved in cellular response to glucose stimulus
positive regulation of growth rate
positive regulation of multicellular organism growth
regulation of cell proliferation
negative regulation of circadian sleep/wake cycle, REM sleep
negative regulation of apoptotic process
cortisol secretion
positive regulation of MAPK cascade
response to estrogen
positive regulation of growth
positive regulation of circadian sleep/wake cycle, non-REM sleep
decidualization
negative regulation of inflammatory response
cartilage development
positive regulation of corticotropin secretion
positive regulation of cortisol secretion
response to electrical stimulus
positive regulation of synapse assembly
regulation of transmission of nerve impulse
positive regulation of growth hormone secretion
positive regulation of growth hormone receptor signaling pathway
postsynaptic modulation of chemical synaptic transmission
regulation of postsynapse organization
positive regulation of small intestinal transit
positive regulation of cold-induced thermogenesis
positive regulation of bone development
positive regulation of sprouting angiogenesis
positive regulation of eating behavior
positive regulation of adipose tissue development
positive regulation of gastro-intestinal system smooth muscle contraction
positive regulation of gastric mucosal blood circulation
positive regulation of small intestine smooth muscle contraction
regulation of gastric motility
positive regulation of vascular endothelial cell proliferation
positive regulation of feeding behavior
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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