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Invitrogen
Kinesin 5B Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA1-19392
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Pig
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Stalk domain of human kinesin, expressed in (aa 331-906) E. coli.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4
Contains
15mM sodium azide
Storage conditions
4°C, do not freeze
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
This antibody detects total level of endogenous kinesin protein (intracellular antigen).
Target Information
Microtubule-dependent motor required for normal distribution of mitochondria and lysosomes. Can induce formation of neurite-like membrane protrusions in non-neuronal cells in a ZFYVE27-dependent manner. Regulates centrosome and nuclear positioning during mitotic entry. During the G2 phase of the cell cycle in a BICD2-dependent manner, antagonizes dynein function and drives the separation of nuclei and centrosomes. Required for anterograde axonal transportation of MAPK8IP3/JIP3 which is essential for MAPK8IP3/JIP3 function in axon elongation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: conventional kinesin heavy chain; epididymis secretory protein Li 61; kinesin 1 (110-120kD); kinesin heavy chain; kinesin heavy chain member 5B, ubiquitous; U-KHC; ubiquitous kinesin heavy chain; unnamed protein product
Gene Aliases: HEL-S-61; Khc; Khcs; KINH; KNS; KNS1; UKHC
UniProt ID: (Human) P33176, (Mouse) Q61768
Entrez Gene ID: (Pig) 595132, (Human) 3799, (Mouse) 16573
microtubule motor activity
protein binding
ATP binding
microtubule binding
ATP-dependent microtubule motor activity, plus-end-directed
ATPase activity
identical protein binding
macromolecular complex binding
cadherin binding
JUN kinase binding
microtubule lateral binding
microtubule binding motor protein
microtubule-based movement
axon guidance
positive regulation of synaptic transmission, GABAergic
lysosome localization
stress granule disassembly
natural killer cell mediated cytotoxicity
regulation of membrane potential
positive regulation of potassium ion transport
vesicle transport along microtubule
synaptic vesicle transport
centrosome localization
anterograde dendritic transport of neurotransmitter receptor complex
regulation of modification of synapse structure, modulating synaptic transmission
anterograde axonal protein transport
positive regulation of protein localization to plasma membrane
anterograde neuronal dense core vesicle transport
retrograde neuronal dense core vesicle transport
mitochondrial transport
microtubule-based process
cytoplasm organization
transport along microtubule
positive regulation of vesicle fusion
positive regulation of insulin secretion involved in cellular response to glucose stimulus
mitochondrion transport along microtubule
cellular response to interferon-gamma
plus-end-directed vesicle transport along microtubule
positive regulation of intracellular protein transport
mitocytosis
positive regulation of voltage-gated sodium channel activity
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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