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Invitrogen
P2X1 Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA1-24622
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Rat
Published species
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
GLQENMRTS Corresponding to residues 364-372 of the rat P2X1.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
Conc. Not Determined
Storage buffer
whole serum
Contains
0.05% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
PA1-24622 is expected to cross react with human (100% conserved) and mouse (100% conserved) due to sequence homology.
Target Information
The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel with relatively high calcium permeability. Binding to ATP mediates synaptic transmission between neurons and from neurons to smooth muscle, being responsible, for example, for sympathetic vasoconstriction in small arteries, arterioles and vas deferens. Mouse studies suggest that this receptor is essential for normal male reproductive function. It is possible that the development of selective antagonists for this receptor may provide an effective non-hormonal male contraceptive pill.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: alternatively spliced; ATP receptor; P2X; P2X1; P2X1b; purinergic receptor P2X, ligand-gated ion channel, 1; RP-2 protein
Gene Aliases: P2XMR
UniProt ID: (Rat) P47824
Entrez Gene ID: (Rat) 25505
serotonin secretion by platelet
regulation of vascular smooth muscle contraction
ion transport
regulation of smooth muscle contraction
insemination
regulation of blood pressure
neuronal action potential
regulation of vasoconstriction
calcium-mediated signaling
platelet activation
response to ATP
ion transmembrane transport
synaptic transmission, glutamatergic
purinergic nucleotide receptor signaling pathway
positive regulation of ion transport
ceramide biosynthetic process
regulation of calcium ion transport
excitatory postsynaptic potential
calcium ion transmembrane transport
cation transmembrane transport
regulation of presynaptic cytosolic calcium ion concentration
positive regulation of calcium ion import across plasma membrane
regulation of synaptic vesicle exocytosis
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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