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Invitrogen
Insulin Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA1-26938
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Published species
Human,
Mouse,
Rat
Host/Isotype
Guinea pig
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Full length human protein.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
0.2 mg/mL
Amount
100 µg
Storage buffer
PBS, pH 7.2, with 0.2% BSA
Contains
0.09% sodium azide
Storage conditions
4°C, do not freeze
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
This antibody stains beta(b) cells of the Langerhan's islets in human pancreas. IHC Note: prolonged fixation in buffered formalin can destroy the epitope.
Target Information
Insulin is a peptide hormone secreted by beta cells of the pancreatic islets. It regulates carbohydrate, protein and lipid metabolism by enhancing membrane transport of glucose, amino acids, and certain ions. It also promotes glycogen storage, formation of triglycerides and synthesis of proteins and nucleic acids. Insulin is 51-amino acid polypeptide product produced from a precursor peptide, proinsulin. Proinsulin is post-translationally cleaved into two chains (peptide A and peptide B) that are covalently linked via two disulfide bonds and one molecule of C-peptide. Insulin deficiency results in diabetes mellitus, one of the leading causes of morbidity and mortality in the general population. Insulin is also present in tumors of b-cell origin such as insulinoma.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Ins; INSU1; INSU2; INSU3B; INSUA; INSUB; INSUC; insulin splice variant; insulin variant; INS-splice; Insulin-1; preproinsulin; proinsulin; unnamed protein product
Gene Aliases: IDDM; IDDM1; IDDM2; ILPR; Ins-1; Ins-2; Ins2-rs1; InsII; IRDN; Mody; MODY10; Mody4; PNDM4
UniProt ID: (Human) P01308, (Mouse) P01325, (Mouse) P01326
Entrez Gene ID: (Human) 3630, (Mouse) 16333, (Mouse) 16334
positive regulation of cytokine production
negative regulation of acute inflammatory response
acute-phase response
G-protein coupled receptor signaling pathway
positive regulation of cell proliferation
insulin receptor signaling pathway
positive regulation of gene expression
negative regulation of gene expression
positive regulation of neuron projection development
regulation of protein localization
response to cytokine
nitric oxide-cGMP-mediated signaling pathway
TORC1 signaling
wound healing
negative regulation of protein catabolic process
vasodilation
glucose homeostasis
positive regulation of I-kappaB kinase/NF-kappaB signaling
positive regulation of MAPK cascade
response to peptide hormone
positive regulation of glycogen biosynthetic process
positive regulation of translation
negative regulation of glycogen catabolic process
positive regulation of glycolytic process
positive regulation of mitotic nuclear division
negative regulation of fatty acid metabolic process
positive regulation of glucose import
positive regulation of insulin receptor signaling pathway
alpha-beta T cell activation
regulation of protein secretion
negative regulation of protein secretion
positive regulation of protein secretion
negative regulation of lipid catabolic process
response to cAMP
positive regulation of protein kinase B signaling
fatty acid homeostasis
relaxation of vascular smooth muscle
negative regulation of respiratory burst involved in inflammatory response
positive regulation of respiratory burst
cellular response to glucose stimulus
positive regulation of protein localization to nucleus
cellular response to oxygen-containing compound
positive regulation of dendritic spine maintenance
regulation of protein localization to plasma membrane
negative regulation of reactive oxygen species biosynthetic process
response to dimethyl sulfoxide
glucose transmembrane transport
neuron projection maintenance
negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
negative regulation of feeding behavior
regulation of transcription, DNA-templated
cell-cell signaling
positive regulation of cell growth
positive regulation of cell migration
positive regulation of cell differentiation
negative regulation of gluconeogenesis
positive regulation of lipid biosynthetic process
regulation of synaptic plasticity
cognition
positive regulation of nitric-oxide synthase activity
positive regulation of peptide hormone secretion
positive regulation of brown fat cell differentiation
positive regulation of long-term synaptic potentiation
negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
negative regulation of transcription from RNA polymerase II promoter
glucose metabolic process
ER overload response
myoblast fusion
regulation of gene expression
myotube differentiation
lipid catabolic process
insulin processing
regulation of phosphorylation
positive regulation of peptidyl-tyrosine phosphorylation
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
positive regulation of ERK1 and ERK2 cascade
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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