Estrogen Receptor beta Antibody

Catalog number: PA1311


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PA1-311 detects estrogen receptor (ER) beta from human, non-human primate, mouse, ovine and rat tissues.

PA1-311 has been successfully used in Western blot, immunohistochemistry, immunocytochemistry and gel shift procedures. By Western blot, this antibody detects an ~55-62 kDa protein representing ER beta from rat brain homogenate. Immunohistochemical staining of ER beta in rat cerebellum with PA1-311 results in cytoplasmic staining in Purkinje neurons. PA1-311 efficiently supershifts rat ER beta/ER response element (vitellogenin xenopus A2 gene).

The PA1-311 immunogen is a synthetic peptide corresponding to residues A(55) E P Q K S P W C E A R S L E H(70) of rat ER beta.

Recombinant ER beta expressed in baculovirus system (Cat. # RP-311 and RP-312) can be purchased for control experiments in Western blot and gel shift assays.

The human ER-beta is a newly discovered estrogen receptor initially cloned and characterized from testis. The size and structure of ER-beta is very similar to ER-alpha with the ligand and DNA binding domains being highly conserved, while the amino terminus which serves as their transactivation domain has diverged significantly. Similar in function to ER-alpha ER-beta binds to estrogen with a high affinity and regulates estrogen specific gene activation through direct interaction with estrogen response elements (ERE's).


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