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Invitrogen
PDE4D Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA1-31136
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
C-terminal cyclic peptide unique to all PDED subtypes variants.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
0.78 mg/mL
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
tris glycine, pH 7.4-4.9, with 0.5% BSA, 30% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
PA1-31136 detects PDE4D from mouse, human, rat samples.
Target Information
This gene encodes one of four mammalian counterparts to the fruit fly 'dunce' gene. The encoded protein has 3',5'-cyclic-AMP phosphodiesterase activity and degrades cAMP, which acts as a signal transduction molecule in multiple cell types. This gene uses different promoters to generate multiple alternatively spliced transcript variants that encode functional proteins.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 3',5'-cyclic AMP phosphodiesterase; alternatively spliced; cAMP-specific 3',5'-cyclic phosphodiesterase 4D; cAMP-specific phosphodiesterase 4D; cAMP-specific phosphodiesterase PDE4D; cAMP-specific phosphodiesterase PDE4D6; cyclic AMP specific phosphodiesterase PDE4D5A; DKFZp686M11213; dunce; FLJ97311; HGNC:8783; HS PDE4DN2; PDE4D1; PDE4D10; PDE4D11; PDE4D2_v1; PDE4D2_v2; PDE4D2_v3; PDE4D3; PDE4D6; PDE4D7; phosphodiesterase 4D, cAMP-specific (phosphodiesterase E3 dunce homolog, Drosophila); splice variant PDE4D4; testicular tissue protein Li 136; unnamed protein product
Gene Aliases: 9630011N22Rik; ACRDYS2; DPDE3; HSPDE4D; PDE3/IVd; PDE43; PDE4DN2; STRK1
UniProt ID: (Human) Q08499, (Rat) P14270, (Mouse) Q01063
Entrez Gene ID: (Human) 5144, (Rat) 24627, (Mouse) 238871
3',5'-cyclic-nucleotide phosphodiesterase activity
3',5'-cyclic-AMP phosphodiesterase activity
calcium channel regulator activity
protein binding
phosphoric diester hydrolase activity
enzyme binding
receptor regulator activity
cAMP binding
beta-2 adrenergic receptor binding
ion channel binding
3',5'-cyclic-GMP phosphodiesterase activity
ATPase binding
scaffold protein binding
heterocyclic compound binding
cyclic-nucleotide phosphodiesterase activity
ovulation from ovarian follicle
positive regulation of protein phosphorylation
regulation of heart rate
cAMP catabolic process
smooth muscle contraction
signal transduction
memory
positive regulation of heart rate
regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
positive regulation of smooth muscle cell migration
positive regulation of cell-cell adhesion
lung development
neutrophil chemotaxis
positive regulation of interferon-gamma production
positive regulation of interleukin-2 production
positive regulation of interleukin-5 production
multicellular organism growth
negative regulation of heart contraction
positive regulation of smooth muscle cell proliferation
T cell receptor signaling pathway
leukocyte migration
establishment of endothelial barrier
protein-containing complex assembly
cellular response to lipopolysaccharide
cellular response to cAMP
cellular response to follicle-stimulating hormone stimulus
cellular response to epinephrine stimulus
adrenergic receptor signaling pathway
regulation of cardiac muscle cell contraction
negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway
cAMP/PKA signal transduction
regulation of cAMP/PKA signal transduction
negative regulation of cAMP/PKA signal transduction
regulation of cell communication by electrical coupling involved in cardiac conduction
negative regulation of relaxation of cardiac muscle
regulation of calcium ion transmembrane transport via high voltage-gated calcium channel
regulation of G-protein coupled receptor protein signaling pathway
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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