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Invitrogen

NOD1 Polyclonal Antibody

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NOD1 Polyclonal Antibody

Product Details

PA1-41036

Applications
Tested Dilution
Publications

Western Blot (WB)

1:1,000-1:2,500
-

Immunohistochemistry (Paraffin) (IHC (P))

1:100
-
Product Specifications

Species Reactivity

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Amino acids 930-949 of human NOD1 protein.
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

Conc. Not Determined

Storage buffer

whole serum with 50% glycerol

Contains

0.025% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2151340

Product Specific Information

Suggested positive control: antigen standard for NOD1 (transient overexpression lysate), recombinant fusion protein.

Predicted to cross react with New World Monkey and Mouse.

Target Information

NOD1 is a member of the NOD (nucleotide-binding oligomerization domain) family, a group of proteins that are involved in innate immune defense. NOD1 contains an N-terminal caspase recruitment domain (CARD), a centrally located nucleotide-binding domain (NBD), and ten tandem leucine-rich repeats (LRRs) in its C-terminus. The CARD is involved in apoptotic signaling, and NOD1 activates caspase-9 and NF-kappa-B. LRRs participate in protein-protein interactions, and mutations in the NBD may affect the process of oligomerization and subsequent function of the LRR domain. This protein is an intracellular pattern-recognition receptor (PRR) that initiates inflammation in response to a subset of bacteria through the detection of bacterial diaminopimelic acid.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: Apaf-1/Ced-4 family member; caspase recruitment domain 4; caspase recruitment domain family, member 4; Caspase recruitment domain-containing protein 4; CED-4/APAF-1 cell death family member; hNod1; mNod1; NLR family, CARD domain containing 1; NOD1; nucleotide-binding oligomerization domain, leucine rich repeat and CARD domain containing 1; Nucleotide-binding oligomerization domain-containing protein 1; unnamed protein product

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Gene Aliases: C230079P11; CARD4; CLR7.1; F830007N14Rik; hNod1; NLRC1; NOD1

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UniProt ID: (Human) Q9Y239, (Mouse) Q8BHB0

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Entrez Gene ID: (Human) 10392, (Mouse) 107607

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Function(s)
nucleotide binding protein binding ATP binding cysteine-type endopeptidase activator activity involved in apoptotic process pattern recognition receptor activity identical protein binding protein homodimerization activity peptidoglycan binding ubiquitin binding macromolecular complex binding CARD domain binding scaffold/adaptor protein
Process(es)
positive regulation of cytokine production pattern recognition receptor signaling pathway immune system process positive regulation of dendritic cell antigen processing and presentation apoptotic process defense response inflammatory response signal transduction JNK cascade detection of biotic stimulus positive regulation of autophagy detection of bacterium positive regulation of interleukin-1 beta production positive regulation of interleukin-6 production positive regulation of interleukin-8 production positive regulation of tumor necrosis factor production positive regulation of stress-activated MAPK cascade response to endoplasmic reticulum stress intracellular signal transduction defense response to bacterium regulation of apoptotic process positive regulation of apoptotic process positive regulation of I-kappaB kinase/NF-kappaB signaling innate immune response positive regulation of JNK cascade defense response to Gram-negative bacterium defense response to Gram-positive bacterium positive regulation of NF-kappaB transcription factor activity stress-activated MAPK cascade positive regulation of macrophage cytokine production ERK1 and ERK2 cascade positive regulation of ERK1 and ERK2 cascade nucleotide-binding oligomerization domain containing 1 signaling pathway cellular response to muramyl dipeptide xenophagy positive regulation of NIK/NF-kappaB signaling positive regulation of xenophagy activation of cysteine-type endopeptidase activity involved in apoptotic process positive regulation of cell death interleukin-8 biosynthetic process positive regulation of cysteine-type endopeptidase activity involved in apoptotic process positive regulation of nitric-oxide synthase activity
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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