Search

  • Order Status
  • Quick Order
  • Promos

Invitrogen

Bcl-10 Polyclonal Antibody

View all (73) BCL-10 antibodies

{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}

{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}

{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}

Datasheet
Certificates
Protocols
Questions & Answers
Datasheet
Certificates
Protocols
Questions & Answers
Datasheet
Certificates
Protocols
Questions & Answers
Additional Information:
{{banner.description}}
{{$ctrl.isSkuNotesCollapsed ? 'View more' : 'View less'}}
Bcl-10 Polyclonal Antibody

Product Details

PA1-4129

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500
-
Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Synthetic peptide corresponding to residues E(220) M F L P L R S R T V S R Q(233) C of Bcl10.
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

Antigen affinity chromatography

Storage buffer

PBS

Contains

0.02% sodium azide

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2063988

Product Specific Information

PA1-4129 detects Bcl10 in human samples.

PA1-4129 has been successfully used in Western blot procedures. By Western blot this antibody detects a ~26 kDa protein representing Bcl10 in transfected 293 cells.

The PA1-4129 immunogen is a synthetic peptide corresponding to residues E(220) M F L P L R S R T V S R Q(233) C of Bcl10.

Target Information

BCL-10 is an N-terminal CARD (Caspase Recruitment Domain) containing protein that is involved in the adaptive immune response. It promotes apoptosis, pro-caspase-9 maturation, and activation of NF-kappa-B via NIK and IKK. BCL-10 is also an adapter protein between upstream TNFR1-TRADD-RIP complex and the downstream NIK-IKK-IKAP complex. It is a substrate for MALT1. Mutations in the gene can lead to Immmunodeficiency 37 or Lymphoma, mucosa-associated lymphoid type.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

References (0)

Have you cited this product in a publication?
Let us know so we can reference it here.
Cite this product

Bioinformatics

Protein Aliases: B cell CLL/lymphoma 10; B-cell CLL/lymphoma 10; bcl-10; CARD containing molecule enhancing NF-kB; CARD-containing apoptotic signaling protein; CARD-containing molecule enhancing NF-kappa-B; CARD-containing proapoptotic protein; CARMEN; caspase-recruiting domain-containing protein; cCARMEN; CED-3/ICH-1 prodomain homologous E10-like regulator; cellular homolog of vCARMEN; cellular-E10; hCLAP; Mamm; mammalian CARD-containing adapter molecule E10; OTTHUMP00000011647; OTTHUMP00000036080; protein binding; signal transducer activity; RP11-234D19.2; unnamed protein product

View more View less

Gene Aliases: c-E10; CARMEN; CIPER; CLAP; IMD37; mE10

View more View less

UniProt ID: (Human) O95999

View more View less

Entrez Gene ID: (Human) 8915

View more View less

Function(s)
protease binding transcription coactivator activity protein binding kinase activator activity protein binding, bridging ubiquitin protein ligase binding signaling adaptor activity identical protein binding protein kinase B binding macromolecular complex binding CARD domain binding NF-kappaB binding general transcription initiation factor binding
Process(es)
positive regulation of cytokine production neural tube closure toll-like receptor signaling pathway adaptive immune response negative regulation of mature B cell apoptotic process apoptotic process programmed cell death positive regulation of protein ubiquitination lipopolysaccharide-mediated signaling pathway response to food response to lipopolysaccharide positive regulation of interleukin-6 production positive regulation of interleukin-8 production positive regulation of lymphotoxin A production positive regulation of mast cell cytokine production NIK/NF-kappaB signaling regulation of apoptotic process positive regulation of apoptotic process regulation of I-kappaB kinase/NF-kappaB signaling positive regulation of I-kappaB kinase/NF-kappaB signaling innate immune response positive regulation of transcription, DNA-templated T cell receptor signaling pathway positive regulation of T cell receptor signaling pathway protein homooligomerization antifungal innate immune response cellular response to lipopolysaccharide cellular response to mechanical stimulus apoptotic signaling pathway positive regulation of extrinsic apoptotic signaling pathway
guarantee_icon

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

Learn more
help_icon

We're here to help

Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.

Contact tech support