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Invitrogen
GluR2/GluR3 Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA1-4660
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Rat
Published species
Mouse,
Non-human primate
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide corresponding to the C-terminal region of rat GRIA2/3 conjugated to KLH
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
0.25 mg/mL
Amount
25 µg
Purification
Affinity chromatography
Storage buffer
0.01M HEPES, pH 7.5, with 0.15M NaCl, 100µg/mL BSA, 50% glycerol
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
This antibody is predicted to react with chicken, human, mouse and zebrafish based on 100% sequence homology.
This antibody is specific for the ~100 kDa GluR2/3 protein.
Target Information
Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. These receptors are heteromeric protein complexes composed of multiple subunits, arranged to form ligand-gated ion channels. The classification of glutamate receptors is based on their activation by different pharmacologic agonists. The subunit encoded by this gene belongs to a family of AMPA (alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate)-sensitive glutamate receptors, and is subject to RNA editing (AGA->GGA; R->G). Alternative splicing at this locus results in different isoforms, which may vary in their signal transduction properties.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: AMPA-selective glutamate receptor 2; AMPA-selective glutamate receptor 3; glutamate receptor; glutamate receptor (GluR-B); glutamate receptor (GluR-C); glutamate receptor B; glutamate receptor, ionotrophic, AMPA 3; glutamate receptor, ionotropic, AMPA 2; glutamate receptor, ionotropic, AMPA 3; glutamate receptor, ionotropic, AMPA3 (alpha 3); GPRC1C; GRM3; MGR3
Gene Aliases: GluA2; GluA3; GluR-3; gluR-B; GluR-C; GluR-K2; GluR-K3; GluR2; GLUR3
UniProt ID: (Rat) P19491, (Rat) P19492
Entrez Gene ID: (Rat) 29627, (Rat) 29628
SNARE binding
beta-amyloid binding
ionotropic glutamate receptor activity
AMPA glutamate receptor activity
ion channel activity
extracellular ligand-gated ion channel activity
extracellular-glutamate-gated ion channel activity
protein binding
cytoskeletal protein binding
ligand-gated ion channel activity
kainate selective glutamate receptor activity
immunoglobulin binding
protein kinase binding
glutamate-gated calcium ion channel activity
PDZ domain binding
glutamate receptor binding
ionotropic glutamate receptor binding
signaling receptor activity
identical protein binding
macromolecular complex binding
scaffold protein binding
ligand-gated monoatomic cation channel activity
ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential
transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential
ligand-gated calcium channel activity
regulation of receptor recycling
ion transport
chemical synaptic transmission
response to lithium ion
calcium-mediated signaling
cerebral cortex development
receptor internalization
ion transmembrane transport
ionotropic glutamate receptor signaling pathway
synaptic transmission, glutamatergic
establishment of protein localization
modulation of synaptic transmission
positive regulation of synaptic transmission
protein tetramerization
regulation of synaptic plasticity by chemical substance
regulation of synaptic transmission, glutamatergic
regulation of postsynaptic membrane potential
excitatory postsynaptic potential
long-term synaptic potentiation
response to fungicide
cellular response to amine stimulus
AMPA glutamate receptor clustering
cation transmembrane transport
regulation of presynaptic membrane potential
regulation of long term synaptic depression
response to phorbol 13-acetate 12-myristate
cellular response to glycine
cellular response to brain-derived neurotrophic factor stimulus
conditioned place preference
positive regulation of excitatory postsynaptic potential
protein homotetramerization
protein heterotetramerization
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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