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Invitrogen
Aurora A Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-110656
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant Protein corresonding to Human Aurora A. Recombinant protein control fragment (Product #RP-102055).
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
0.2 mg/mL
Amount
20 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: ISGPVKATAP VGGPKRVLVT QQFPCQNPLP VNSGQAQRVL CPSNSSQRVP LQAQKLVSSH KPVQNQKQKQ LQATSVPHPV SRPLNNTQKS KQPLPSAPEN NPEEELASKQ KNEESKKRQW ALEDFEIGRP LGKGKFGNVY L
Highest antigen sequence indentity to the following orthologs: Mouse - 66%, Rat - 67%.
Target Information
AURKA (Aurora A) is a serine/threonine kinase that regulates mitosis by association in vivo with centrosomes. Overexpression of AURKA is observed in many types of cancer. Aurora A plays a role in cell cycle regulation during anaphase and/or telophase, in relation to the function of the centrosome/spindle pole region during chromosome segregation. Aurora A plays a key role during tumor development and progression and is overexpressed in many human cancers including breast, ovarian and colorectal. Aurora A is viewed as a potential target for anticancer drug treatment. Tissue specificity: Highly expressed in testis and weakly in skeletal muscle, thymus and spleen.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: AURAK; aurora 2; Aurora A Kinase; aurora/IP; aurora/IPL1-like kinase; aurora/IPL1-related kinase 1; AURORA2; breast tumor-amplified kinase; EC 2.7.11.1; hARK1; IPL1-related kinase; MGC34538; OTTHUMP00000031341; OTTHUMP00000166072; protein phosphatase 1, regulatory subunit 47; RP5-1167H4.6; serine/threonine protein kinase 15; serine/threonine-protein kinase 6; serine/threonine-protein kinase aurora-A; unnamed protein product
Gene Aliases: AIK; ARK1; AURA; BTAK; PPP1R47; STK15; STK6; STK7
UniProt ID: (Human) O14965
Entrez Gene ID: (Human) 6790
G2/M transition of mitotic cell cycle
meiotic spindle organization
microtubule cytoskeleton organization
mitotic cell cycle
protein phosphorylation
spindle organization
mitotic spindle organization
centrosome cycle
mitotic centrosome separation
response to wounding
regulation of G2/M transition of mitotic cell cycle
negative regulation of gene expression
peptidyl-serine phosphorylation
regulation of protein stability
negative regulation of protein binding
regulation of cytokinesis
regulation of microtubule-based process
cell cycle G2/M phase transition
positive regulation of mitotic nuclear division
positive regulation of mitotic cell cycle
regulation of centrosome cycle
protein autophosphorylation
meiotic cell cycle
cilium disassembly
positive regulation of cell cycle process
positive regulation of mitochondrial fission
liver regeneration
regulation of signal transduction by p53 class mediator
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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