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Invitrogen
CD148 Polyclonal Antibody
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Product Details
PA5-110703
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant Protein corresonding to Human CD148. Recombinant protein control fragment (Product #RP-102094).
Conjugate
Form
Liquid
Concentration
0.1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: SSNATQVVTD IGITDATVTE LIPGSSYTVE IFAQVGDGIK SLEPGRKSFC TDPASMASFD CEVVPKEPAL VLKWTCPPGA NAGFELEVSS GAWNNATHLE SCSSENGTEY RTEVTYLNFS TSYNISITTV SCGKMAAPTR NTCTTG
Highest antigen sequence indentity to the following orthologs: Rat - 63%, Mouse - 59%.
Target Information
CD148 is a highly glycosylated transmembrane protein of up to 250 kDa, containing eight fibronectin type III domains in the extracellular region and one tyrosine phosphatase domain in the cytoplasmic region. Expression is found broadly on fibroblasts, epithelial cells, lymphocytes (B, T and NK cells), and myeloid cells (monocytes and granulocytes). CD148 can dephosphorylate proteins such as LAT and PLC-gamma, and is involved in the downregulation of T cell activation. Conversely, CD148 expression can be upregulated following T cell activation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CD148; CD148 antigen; Density-enhanced phosphatase 1; DEP-1; HPTP eta; human density enhanced phosphatase-1; protein tyrosine phosphatase, receptor type, J polypeptide; Protein-tyrosine phosphatase eta; Protein-tyrosine phosphatase receptor type J; R-PTP-J; Receptor-type tyrosine-protein phosphatase eta; susceptibility to colon cancer 1, mouse, homolog of
Gene Aliases: CD148; DEP1; HPTPeta; PTPRJ; R-PTP-ETA; SCC1
UniProt ID: (Human) Q12913
Entrez Gene ID: (Human) 5795
protein tyrosine phosphatase activity
platelet-derived growth factor receptor binding
protein binding
beta-catenin binding
phosphatase activity
protein kinase binding
gamma-catenin binding
mitogen-activated protein kinase binding
delta-catenin binding
extracellular matrix protein
transmembrane signal receptor
negative regulation of cell proliferation
negative regulation of platelet-derived growth factor receptor signaling pathway
regulation of cell adhesion
negative regulation of cell growth
negative regulation of cell migration
peptidyl-tyrosine dephosphorylation
negative regulation of epidermal growth factor receptor signaling pathway
negative regulation of vascular permeability
negative regulation of MAP kinase activity
positive regulation of cell adhesion
platelet-derived growth factor receptor signaling pathway
T cell receptor signaling pathway
negative regulation of T cell receptor signaling pathway
positive chemotaxis
positive regulation of focal adhesion assembly
positive regulation of protein kinase B signaling
negative regulation of protein kinase B signaling
contact inhibition
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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