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Invitrogen
ALPL Polyclonal Antibody
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FIGURE: 1 / 5
ALPL Antibody (PA5-110719) in IHC (P)
Immunohistochemistry analysis of ALPL in human adrenal gland, endometrium, liver and pancreas. Samples were incubated with ALPL polyclonal antibody (Product # PA5-110719). Shows similar protein distribution across tissues to independent ALPL antibody (Product # PA5-82363) (B).
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-110719
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant Protein corresonding to Human ALPL. Recombinant protein control fragment (Product #RP-89766).
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
0.05 mg/mL
Amount
5 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: LTSSEDTLTV VTADHSHVFT FGGYTPRGNS IFGLAPMLSD TDKKPFTAIL YGNGPGYKVV GGERENVSMV DYAHNNYQAQ SAVPLRHETH GGEDVAVFSK GPMAHLLHGV HEQNYVPHVM AYAACIGANL
Highest antigen sequence indentity to the following orthologs: Mouse - 94%, Rat - 94%.
Target Information
Alkaline phosphatase is a homodimeric protein enzyme (86 kDa), containing two zinc atoms crucial to its catalytic function per monomer, and it is optimally active at alkaline pH environments. The enzyme is found in prokaryotes and eukaryotes, with the same general function but in different structural forms suitable to organism's environment. ALP plays a role in liver metabolism and development within the skeleton. In bacteria, ALP acts as a source of inorganic phosphate. In yeast, ALP can be a useful protein for studying membrane protein sorting.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: alkaline phosphatase liver/bone/kidney isozyme; alkaline phosphatase, liver/bone/kidney; FLJ40094; FLJ93059; glycerophosphatase; liver/bone/kidney-type alkaline phosphatase; MGC161443; MGC167935; phosphoamidase; phosphocreatine phosphatase; tissue non-specific alkaline phosphatase; tissue-nonspecific ALP; unnamed protein product
Gene Aliases: AP-TNAP; APTNAP; HOPS; HPPA; HPPC; HPPI; HPPO; TNALP; TNAP; TNS-ALP; TNSALP
UniProt ID: (Human) P05186
Entrez Gene ID: (Human) 249
skeletal system development
osteoblast differentiation
bone mineralization
response to lipopolysaccharide
response to insulin
response to vitamin D
response to vitamin B6
response to macrophage colony-stimulating factor
pyridoxal phosphate metabolic process
response to glucocorticoid
phosphate ion homeostasis
calcium ion homeostasis
cementum mineralization
positive regulation of cold-induced thermogenesis
futile creatine cycle
inhibition of non-skeletal tissue mineralization
response to sodium phosphate
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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