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Invitrogen
WISP1 Polyclonal Antibody
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Product Details
PA5-110720
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant Protein corresonding to Human WISP1. Recombinant protein control fragment (Product #RP-88739).
Conjugate
Form
Liquid
Concentration
0.2 mg/mL
Amount
20 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: QVVGVGCVLD GVRYNNGQSF QPNCKYNCTC IDGAVGCTPL CLRVRPPRLW CPHPRRVSIP GHCCEQWVCE DDAKRPRKTA PRDTGAF
Highest antigen sequence indentity to the following orthologs: Mouse - 79%, Rat - 79%.
Target Information
This gene encodes a member of the WNT1 inducible signaling pathway (WISP) protein subfamily, which belongs to the connective tissue growth factor (CTGF) family. WNT1 is a member of a family of cysteine-rich, glycosylated signaling proteins that mediate diverse developmental processes. The CTGF family members are characterized by four conserved cysteine-rich domains: insulin-like growth factor-binding domain, von Willebrand factor type C module, thrombospondin domain and C-terminal cystine knot-like domain. This gene may be downstream in the WNT1 signaling pathway that is relevant to malignant transformation. It is expressed at a high level in fibroblast cells, and overexpressed in colon tumors. The encoded protein binds to decorin and biglycan, two members of a family of small leucine-rich proteoglycans present in the extracellular matrix of connective tissue, and possibly prevents the inhibitory activity of decorin and biglycan in tumor cell proliferation. It also attenuates p53-mediated apoptosis in response to DNA damage through activation of the Akt kinase. It is 83% identical to the mouse protein at the amino acid level. Alternative splicing of this gene generates 2 transcript variants.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CCN family member 4; unnamed protein product; WISP-1; WISP1 3'UTR-associated RNA 1; WISP1 overlapping transcript 1 (non-protein coding); WISP1vx; Wnt-1-induced secreted protein; WNT1 induced secreted protein 1; WNT1 inducible signaling pathway protein 1; WNT1-inducible-signaling pathway protein 1
Gene Aliases: CCN4; WISP1; WISP1-OT1; WISP1-UT1; WISP1c; WISP1i; WISP1tc
UniProt ID: (Human) O95388
Entrez Gene ID: (Human) 8840
osteoblast differentiation
regulation of cytokine production
cell adhesion
signal transduction
cell-cell signaling
positive regulation of smooth muscle cell migration
Wnt signaling pathway
positive regulation of Wnt signaling pathway
osteoclast differentiation
negative regulation of chondrocyte differentiation
glucose homeostasis
regulation of cell differentiation
positive regulation of cell differentiation
negative regulation of fat cell differentiation
positive regulation of osteoblast differentiation
positive regulation of smooth muscle cell proliferation
positive regulation of inflammatory response
regulation of multicellular organismal process
bone development
positive regulation of wound healing
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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