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Invitrogen
MAGI3 Polyclonal Antibody
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Product Details
PA5-110738
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant Protein corresonding to Human MAGI3. Recombinant protein control fragment (Product #RP-89519).
Conjugate
Form
Liquid
Concentration
0.1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: LKVGDHISAV NGQSIVELSH DNIVQLIKDA GVTVTLTVIA EEEHHGPPSG TNSARQSPAL QHRPMGQSQA NHIPGDRSAL EGEIGKDVST SYRHSWSDHK HLAQPDTAVI SVVGSRHNQN LGCYPVELER GPRGFGFSLR G
Highest antigen sequence indentity to the following orthologs: Mouse - 94%, Rat - 93%.
Target Information
Membrane-associated guanylate kinase with inverted orientation (MAGI3) is a novel, 130 kDa guanylate kinase which is part of a family of multi-PDZ domain containing guanylate kinases. These guanylate kinases are localized to epithelial cell tight junctions. MAGI3 and PTEN/MMAC cooperate to modulate the kinase activity of AKT/protein kinase B (PKB). MAGI3 positions the PTEN/MMAC phosphatase to specific subcellular locations that are involved with the regulation of cell proliferation and survival. MAGI3, as well as other proteins in this family, are made up of an N-terminal guanylate kinase domain, followed by a WW domain, named for two conserved tryptophan residues and first identified as two repeats in mouse YAP65, which is them followed by 5 PDZ domains.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: GKWW domain; MAGI-3; Membrane-associated guanylate kinase inverted 3; Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 3; membrane-associated guanylate kinase-related 3; PDZ 4-5; RP4-730K3.1
Gene Aliases: dJ730K3.2; KIAA1634; MAGI-3; MAGI3
UniProt ID: (Human) Q5TCQ9
Entrez Gene ID: (Human) 260425
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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