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Invitrogen
M-cadherin Polyclonal Antibody
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Product Details
PA5-110758
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant Protein corresonding to Human M-cadherin. Recombinant protein control fragment (Product #RP-90195).
Conjugate
Form
Liquid
Concentration
0.10 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: TFSARDPDTE QLQRLSYSKD YDPEDWLQVD AATGRIQTQH VLSPASPFLK GGWYRAIVLA QDDASQPRTA TGTLSIEILE VNDHAPVLAP PPPGSLCSEP HQGPGLLLGA TDEDLPPHGA PFHFQLSPRL PELGRNWSLS QVNVSH
Highest antigen sequence indentity to the following orthologs: Mouse - 87%, Rat - 88%.
Target Information
Cadherins are a multigene family of Ca++-dependent cell adhesion molecules. They are transmembrane glycoproteins consisting of an extracellular domain, which mediates Ca++-dependent intercellular adhesion by homophilic interactions, a transmembrane region and a cytoplasmic domain. The extracellular domain is divided into a series of subdomains designated EC1-EC5. Homolgies between different members of the cadherin family are most prominent in the cytoplasmic domain and in EC1 and EC2 and much less so in EC5 of the extracellular domain and in the transmembrane region. The binding properties and specificities of the adhesive function are located in the N-terminal part of the molecules. Four members of the cadherin family have been identified and molecularly cloned from mammalian cells. These include the neuronal (N), epithelial (E), placental (P) and muscle (M) cadherins. M-cadherin is not found in fibroblasts but is expressed at low level in myoblasts and is upregulated following induction of myotube formation, suggesting a specific function in skeletal muscle cell differentiation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: cadherin 15, type 1, M-cadherin (myotubule); Cadherin-14; Cadherin-15; cadherin-3; CRSBP-1; HAR; LYVE-1; M-cadherin; Muscle cadherin; muscle-cadherin; XLKD1
Gene Aliases: CDH14; CDH15; CDH3; CDHM; MCAD; MRD3
UniProt ID: (Human) P55291
Entrez Gene ID: (Human) 1013
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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