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Caspase 6 Polyclonal Antibody
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FIGURE: 1 / 4
Caspase 6 Antibody (PA5-110766) in IHC (P)
Immunohistochemical analysis of Caspase 6 in human small intestine and skeletal muscle tissues using Caspase 6 Polyclonal Antibody (Product # PA5-110766) using Anti-CASP6 antibody. Corresponding CASP6 RNA-seq data are presented for the same tissues.
Product Details
PA5-110766
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant Protein corresonding to Human Caspase 6. Recombinant protein control fragment (Product #RP-89270).
Conjugate
Form
Liquid
Concentration
0.1 mg/mL
Amount
10 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: DVPVIPLDVV DNQTEKLDTN ITEVDAASVY TLPAGADFLM CYSVAEGYYS HRETVNGSWY IQDLCEMLGK YGSSLEFTEL LTLVNRKVSQ RRVDFCKDPS AIGKKQV
Highest antigen sequence indentity to the following orthologs: Mouse - 91%, Rat - 91%.
Target Information
Caspases are cysteine proteases, expressed as inactive precursors, that mediate apoptosis by proteolysis of specific substrates. Caspases have the ability to cleave after aspartic acid residues. There are two classes of caspases involved in apoptosis; initiators (activation by receptor cluster) and effectors (activation by mitochondrial permeability transition). Proapoptotic signals autocatalytically activate initiator caspases, such as Caspase-8 and Caspase 9. Activated initiator caspases then process effector caspases, such as Caspase-3 and Caspase-7, which in turn cause cell collapse.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Apoptotic protease Mch-2; CASP-6; caspase 6, apoptosis-related cysteine peptidase; caspase 6, apoptosis-related cysteine protease; Caspase-6; mammalian Ced-3 homologue 2; mCASP-6
Gene Aliases: CASP6; caspase-6; CSP-6; MCH2
UniProt ID: (Human) P55212
Entrez Gene ID: (Human) 839
activation of innate immune response
proteolysis
apoptotic process
protein autoprocessing
epithelial cell differentiation
positive regulation of apoptotic process
regulation of programmed cell death
positive regulation of neuron apoptotic process
protein maturation
positive regulation of necroptotic process
pyroptosis
intrinsic apoptotic signaling pathway by p53 class mediator
cellular response to staurosporine
positive regulation of release of cytochrome c from mitochondria
hepatocyte apoptotic process
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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