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Invitrogen
CBX4 Polyclonal Antibody
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Product Details
PA5-110770
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant Protein corresonding to Human CBX4. Recombinant protein control fragment (Product #RP-105723).
Conjugate
Form
Liquid
Concentration
0.05 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: SPKYNTWEPE ENILDPRLLI AFQNRERQEQ LMGYRKRGPK PKPLVVQVPT FARRSNVLTG LQDSSTDNRA KLDSGAEEK
Highest antigen sequence indentity to the following orthologs: Mouse - 92%, Rat - 92%.
Target Information
Polycomb group (PcG) proteins are chromatin-associated proteins which are important for embryonic and adult stem cell self-renewal and maintenance. At least two distinct human PcG complexes have been identified. Polycomb repressive complex I (PRC1) contains CBX4/Pc2, HPH1 and RING domain-containing proteins (RING1, RING2 and BMI1). CBX4 (Chromobox protein homolog 4 or PC2), which functions as a transcriptional suppressor, is a candidate of KyoT2-binding proteins. It is a E3 SUMO-protein ligase which facilitates SUMO1 conjugation. Depletion of CBX4 results in decreased cellular resistance to ionizing radiation. CBX4 is directly involved in the cellular response to DNA damage.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: chromobox homolog 4 (Pc class homolog, Drosophila); Chromobox protein homolog 4; chromobox-like protein 4; E3 SUMO-protein ligase CBX4; hPc2; NS5ATP1-binding protein 16; Pc class 2 homolog; Pc2; Polycomb 2 homolog
Gene Aliases: CBX4; NBP16; PC2
UniProt ID: (Human) O00257
Entrez Gene ID: (Human) 8535
chromatin binding
transcription corepressor activity
single-stranded RNA binding
protein binding
ligase activity
SUMO transferase activity
enzyme binding
SUMO binding
methylated histone binding
transcription regulatory region DNA binding
phosphoprotein binding
ubiquitin-protein ligase
protein modifying enzyme
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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