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Invitrogen
SLITRK1 Polyclonal Antibody
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Product Details
PA5-110773
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant Protein corresonding to Human SLITRK1. Recombinant protein control fragment (Product #RP-90499).
Conjugate
Form
Liquid
Concentration
0.2 mg/mL
Amount
20 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: GNRLKTLPYE EVLEQIPGIA EILLEDNPWD CTCDLLSLKE WLENIPKNAL IGRVVCEAPT RLQGKDLNET TEQDLCPLKN RVDSSLPAPP AQEETFAPGP LPTPFKTNGQ EDHATPGSAP NGGTKIPGNW QIKIRPTAAI ATGSSRNKP
Highest antigen sequence indentity to the following orthologs: Rat - 93%, Mouse - 94%.
Target Information
SLIT and NTRK-like family 1 (Slitrk1) is a member a protein family consisting of six homologous transmembrane proteins (Slitrk1-6) that share two conserved leucine-rich repeat domains in the extracellular domain and have significant homology to Slit, a secreted axonal growth-controlling protein. These proteins are also homologous to trk neurotrophin receptors in their intracellular domains. Expression of Slitrk proteins is highly restricted to neural and brain tumor tissues, but varies within the family. For example, Slitrk1 is expressed primarily in mature neurons. Overexpression of Slitrk1 in transfected neuronal cells induced unipolar neurites, while expression of the other Slitrk proteins inhibited neurite outgrowth, suggesting that these proteins are involved in the control of neurite outgrowth. While Slitrk1 variants have been suggested associated with Tourette's Syndrome, it is thought to play only a minor role if at all.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Leucine-rich repeat-containing protein 12; RP11-395N17.1; SLIT and NTRK-like protein 1; slit and trk like gene 1; unnamed protein product
Gene Aliases: KIAA1910; LRRC12; SLITRK1; TTM; UNQ233/PRO266
UniProt ID: (Human) Q96PX8
Entrez Gene ID: (Human) 114798
endocytosis
nervous system development
axonogenesis
synapse assembly
gene expression
adult behavior
multicellular organism growth
norepinephrine metabolic process
homeostatic process
positive regulation of axonogenesis
positive regulation of synapse assembly
vocalization behavior
synaptic membrane adhesion
regulation of presynapse assembly
neuron projection extension
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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