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Invitrogen
DYRK1A Polyclonal Antibody
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Product Details
PA5-110809
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant Protein corresonding to Human DYRK1A. Recombinant protein control fragment (Product #RP-91461).
Conjugate
Form
Liquid
Concentration
0.10 mg/mL
Amount
10 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: HTGGETSACK PSSVRLAPSF SFHAAGLQMA GQMPHSHQYS DRRQPNISDQ QVSALSYSDQ IQQPLTNQ
Highest antigen sequence indentity to the following orthologs: Mouse - 96%, Rat - 99%.
Target Information
DYRK1A is a dual specificity kinase involved in cell proliferation. The gene for DYRK1A is located in the Down syndrome critical region of chromosome 21, and has been implicated in the pathogenesis of this disease. DYRK1A catalyzes the transition of 3-phosphoglycerate into 3-phosphohydroxypyruvate, which is the first and rate-limiting step in the phosphorylated pathway of serine biosynthesis, using NAD+/NADH as a cofactor.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: dual specificity tyrosine-(Y)-phosphorylation regulated kinase 1A; Dual specificity tyrosine-phosphorylation-regulated kinase 1A; Dual specificity YAK1-related kinase; HP86; mnb protein kinase homolog hp86; MNB/DYRK protein kinase; MNBH; OTTHUMP00000109090; Protein kinase minibrain homolog; serine/threonine kinase MNB; serine/threonine-specific protein kinase; unnamed protein product
Gene Aliases: DYRK; DYRK1; DYRK1A; HP86; MNB; MNBH; MRD7
UniProt ID: (Human) Q13627
Entrez Gene ID: (Human) 1859
nucleotide binding
transcription coactivator activity
actin binding
protein kinase activity
protein serine/threonine kinase activity
protein serine/threonine/tyrosine kinase activity
protein tyrosine kinase activity
non-membrane spanning protein tyrosine kinase activity
protein binding
ATP binding
cytoskeletal protein binding
RNA polymerase II carboxy-terminal domain kinase activity
tubulin binding
kinase activity
transferase activity
identical protein binding
tau protein binding
tau-protein kinase activity
protein serine kinase activity
histone H3T45 kinase activity
splicing factor binding
regulation of alternative mRNA splicing, via spliceosome
double-strand break repair via homologous recombination
double-strand break repair via nonhomologous end joining
chromatin remodeling
regulation of transcription from RNA polymerase II promoter
protein phosphorylation
nervous system development
circadian rhythm
peptidyl-tyrosine phosphorylation
negative regulation of microtubule polymerization
negative regulation of heterochromatin assembly
positive regulation of RNA splicing
negative regulation of DNA damage response, signal transduction by p53 class mediator
positive regulation of transcription, DNA-templated
protein autophosphorylation
negative regulation of mRNA splicing, via spliceosome
regulation of beta-amyloid formation
regulation of neurofibrillary tangle assembly
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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