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Invitrogen
PSMC5 Polyclonal Antibody
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Product Details
PA5-110830
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant Protein corresonding to Human PSMC5. Recombinant protein control fragment (Product #RP-91605).
Conjugate
Form
Liquid
Concentration
0.10 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: LDSALLRPGR IDRKIEFPPP NEEARLDILK IHSRKMNLTR GINLRKIAEL MPGASGAEVK GVCTEAGMYA LRERRVHVTQ EDFEMAVAKV MQKDSEKNMS IKKLWK
Highest antigen sequence indentity to the following orthologs: Rat - 100%, Mouse - 100%.
Target Information
Human SUG1 (also known as p45, Rpt6 and Cim3) is a component of the 19S regulatory subunit of the 26S proteosome complex. It is one of the AAA ATPas found in the 19S regulatory complex that is thought to participate in the unfolding of ubiquitinated proteins in an ATP-dependent manner. It has also been shown to directly interact with the nucleotide excision repair protein XPB.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 26S protease regulatory subunit 8; 26S proteasome AAA-ATPase subunit RPT6; 26S proteasome regulatory subunit 8; for proteasomal ATPase (SUG1); mSUG1; MSUG1 protein; p45/SUG; peptidase (prosome, macropain) 26S subunit, ATPase 5; protease (prosome, macropain) 26S subunit, ATPase 5; proteasomal ATPase (SUG1); proteasome (prosome, macropain) 26S subunit, ATPase, 5; proteasome 26S ATPase subunit 5; Proteasome 26S subunit ATPase 5; proteasome p45/SUG; Proteasome subunit p45; similar to 26S proteasome subunit p45; Tat-binding protein homolog 10; testicular tissue protein Li 149; thy; Thyroid hormone receptor-interacting protein 1; thyroid receptor interactor 1; TRIP1; unnamed protein product
Gene Aliases: mSUG1; p45; p45/SUG; PSMC5; RPT6; S8; SUG-1; SUG1; TBP10; TRIP1
UniProt ID: (Human) P62195, (Mouse) P62196, (Rat) P62198
Entrez Gene ID: (Human) 5705, (Mouse) 19184, (Rat) 81827
nucleotide binding
receptor binding
protein binding
ATP binding
transcription factor binding
ATPase activity
TBP-class protein binding
thyrotropin-releasing hormone receptor binding
proteasome-activating ATPase activity
general transcription initiation factor binding
DNA-binding transcription factor binding
hydrolase activity
protease
regulation of transcription from RNA polymerase II promoter
negative regulation of programmed cell death
proteasome-mediated ubiquitin-dependent protein catabolic process
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
positive regulation of inclusion body assembly
positive regulation of proteasomal protein catabolic process
protein catabolic process
ER-associated ubiquitin-dependent protein catabolic process
positive regulation of RNA polymerase II transcriptional preinitiation complex assembly
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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