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Invitrogen
LGP2 Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-110851
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant Protein corresonding to Human LGP2. Recombinant protein control fragment (Product #RP-92403).
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
0.2 mg/mL
Amount
20 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: GLLTNEISMV QARGRARADQ SVYAFVATEG SRELKRELIN EALETLMEQA VAAVQKMDQA EYQAKIRDLQ QAALTKRAAQ AAQRENQRQQ FPVEHVQLLC INCMVAV
Highest antigen sequence indentity to the following orthologs: Rat - 80%, Mouse - 81%.
Target Information
Anti-viral innate immune responses are triggered by pathogen-associated molecular patters (such as the accumulation of intracellular nucleic acids resulting from virus infections) and represent the first line of defense against numerous infectious organisms. The Toll-like receptors (TLR) 3, 7, 8, and 9 are expressed in immune cells and function as transmembrane pattern recognition receptors to detect foreign nucleic acids. Other proteins that play similar roles, such as RIG-1 and MDA5 are members of a CARD-helicase family and are expressed in the cytoplasm. A third protein, LGP2, is similar to RIG-1 and MDA5, except for lacking a homologous CARD domain. It is thought to act as an element of negative-feedback regulation of intracellular antiviral signaling. At least four isoforms of LGP2 are known to exist.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: ATP-dependent helicase LGP2; DEXH (Asp-Glu-X-His) box polypeptide 58; ortholog of mouse D11lgp2; probable ATP-dependent helicase LGP2; probable ATP-dependent RNA helicase DHX58; protein D11Lgp2 homolog; RIG-I-like receptor 3; RIG-I-like receptor LGP2; RLR; RNA helicase LGP2; unnamed protein product
Gene Aliases: D11LGP2; D11lgp2e; LGP2; RLR-3
UniProt ID: (Human) Q96C10
Entrez Gene ID: (Human) 79132
cytoplasmic pattern recognition receptor signaling pathway
response to virus
negative regulation of type I interferon production
positive regulation of type I interferon production
negative regulation of MDA-5 signaling pathway
negative regulation of RIG-I signaling pathway
regulation of innate immune response
negative regulation of innate immune response
antiviral innate immune response
positive regulation of MDA-5 signaling pathway
positive regulation of RIG-I signaling pathway
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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