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Invitrogen
CMG1 Polyclonal Antibody
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Product Details
PA5-110859
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant Protein corresonding to Human CMG1. Recombinant protein control fragment (Product #RP-92896).
Conjugate
Form
Liquid
Concentration
0.05 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: ELQGQLADYN MLVDKLNTNT EMEEVMNDYN MLKAQNDRET QSLDVIFTER QAKEKQIRSV EEEIEQEKQA TDDIIKNMSF ENQVKYLEMK TTNEKLLQE
Highest antigen sequence indentity to the following orthologs: Mouse - 90%, Rat - 91%.
Target Information
This gene encodes a core intraflagellar transport (IFT) protein which belongs to a multi-protein complex involved in the transport of ciliary proteins along axonemal microtubules. IFT proteins are found at the base of the cilium as well as inside the cilium, where they assemble into long arrays between the ciliary base and tip. This protein, together with intraflagellar transport protein 81, binds and transports tubulin within cilia and is required for ciliogenesis. Naturally occurring mutations in this gene are associated with amyotrophic lateral sclerosis--frontotemporal dementia and Bardet-Biedl Syndrome.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Capillary morphogenesis gene 1 protein; capillary morphogenesis protein 1; CMG-1; CMG-1; with coiled-coil domains; coiled-coil domain containing 2; Coiled-coil domain-containing protein 2; intraflagellar transport 74 homolog; Intraflagellar transport protein 74 homolog; unnamed protein product
Gene Aliases: BBS22; CCDC2; CMG-1; CMG1; IFT74; JBTS40; SPGF58
UniProt ID: (Human) Q96LB3
Entrez Gene ID: (Human) 80173
keratinocyte development
Notch signaling pathway
determination of left/right symmetry
heart development
epidermis development
negative regulation of keratinocyte proliferation
cell projection organization
positive regulation of cell adhesion mediated by integrin
intraciliary anterograde transport
intraciliary transport involved in cilium morphogenesis
intraciliary transport
keratinocyte proliferation
positive regulation of transcription from RNA polymerase II promoter
negative regulation of epithelial cell proliferation
cilium morphogenesis
non-motile cilium assembly
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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