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Invitrogen
Dystrophin Polyclonal Antibody
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Product Details
PA5-110894
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant Protein corresonding to Human Dystrophin. Recombinant protein control fragment (Product #RP-92153).
Conjugate
Form
Liquid
Concentration
0.3 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: KQNDVHRAFK RELKTKEPVI MSTLETVRIF LTEQPLEGLE KLYQEPRELP PEERAQNVTR LLRKQAEEVN TEWEKLNLHS ADWQRKIDET LERLQELQEA TDELDLKLRQ AEVIKGSWQP VGDLLIDSLQ DHLEKVKALR GEIAPLKENV
Highest antigen sequence indentity to the following orthologs: Mouse - 96%, Rat - 98%.
Target Information
Dystrophin is the 427kDa protein product of the DMB/BMD gene located on the X chromosome at position Xp21. Western blotting and immunohistochemistry are the two established methods for the detection of abnormalities of dystrophin expression in muscle biopsies. Dystrophin abnormalities are thought to occur in 100% of patients with DMD/BMD, although genetic abnormalities may only be detected in up to 65% of cases.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Duchenne muscular dystrophy (DMD); Dystrophin; GS1-19O24.1; Muscular dystrophy Duchenne and Becker types; OTTHUMP00000215592
Gene Aliases: BMD; CMD3B; DMD; DXS142; DXS164; DXS206; DXS230; DXS239; DXS268; DXS269; DXS270; DXS272; MRX85
UniProt ID: (Human) P11532
Entrez Gene ID: (Human) 1756
regulation of heart rate
cytoskeleton organization
muscle organ development
regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion
regulation of skeletal muscle contraction
muscle attachment
muscle filament sliding
negative regulation of peptidyl-serine phosphorylation
cellular protein localization
response to muscle stretch
peptide biosynthetic process
cellular protein complex assembly
muscle cell cellular homeostasis
muscle fiber development
cardiac muscle contraction
regulation of ryanodine-sensitive calcium-release channel activity
cardiac muscle cell action potential
regulation of voltage-gated calcium channel activity
negative regulation of peptidyl-cysteine S-nitrosylation
positive regulation of sodium ion transmembrane transporter activity
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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