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Invitrogen
ALS2CR2 Polyclonal Antibody
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Product Details
PA5-110917
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant Protein corresonding to Human ALS2CR2. Recombinant protein control fragment (Product #RP-95062).
Conjugate
Form
Liquid
Concentration
0.30 mg/mL
Amount
30 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: VPFQDMHRTQ MLLQKLKGPP YSPLDISIFP QSESRMKNSQ SGVDSGIGES VLVSSGTHTV NSDRLHTPSS
Highest antigen sequence indentity to the following orthologs: Rat - 91%, Mouse - 93%.
Target Information
This gene encodes a protein that belongs to the serine/threonine protein kinase STE20 subfamily. One of the active site residues in the protein kinase domain of this protein is altered, and it is thus a pseudokinase. This protein is a component of a complex involved in the activation of serine/threonine kinase 11, a master kinase that regulates cell polarity and energy-generating metabolism. This complex regulates the relocation of this kinase from the nucleus to the cytoplasm, and it is essential for G1 cell cycle arrest mediated by this kinase. The protein encoded by this gene can also interact with the X chromosome-linked inhibitor of apoptosis protein, and this interaction enhances the anti-apoptotic activity of this protein via the JNK1 signal transduction pathway. Two pseudogenes, located on chromosomes 1 and 7, have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 2; Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 2 protein; Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 2 protein homolog; CALS-21; ILP-interacting protein; ILP-interacting protein homolog; ILP-interacting protein ILPIPA; MGC102916; polyploidy associated protein kinase; Polyploidy-associated protein kinase; predicted protein of HQ1038; Pseudokinase ALS2CR2; STE20-related kinase adapter protein beta; STE20-related kinase adaptor beta; STRAD beta; unnamed protein product
Gene Aliases: AA792893; ALS2CR2; B830008M19; CALS-21; D1Ucla2; ILPIP; ILPIPA; PAPK; PRO1038; STRADB; Syradb
UniProt ID: (Human) Q9C0K7, (Mouse) Q8K4T3
Entrez Gene ID: (Human) 55437, (Mouse) 227154
cell morphogenesis
protein phosphorylation
protein export from nucleus
JNK cascade
activation of protein kinase activity
negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
cytoskeleton organization
cell cycle
Rho protein signal transduction
regulation of mitotic cell cycle
cell migration
actin cytoskeleton organization
regulation of MAPK cascade
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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