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Invitrogen
RANK Polyclonal Antibody
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Product Details
PA5-110945
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant Protein corresonding to Human RANK. Recombinant protein control fragment (Product #RP-90287).
Conjugate
Form
Liquid
Concentration
0.10 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: KESSGDSCVS THTANFGQQG ACEGVLLLTL EEKTFPEDMC YPDQGGVCQG TCVGGGPYAQ GEDARMLSLV SKTEIEEDSF RQMPTEDEYM DRPSQPTDQL LFLTEPGSKS TPPFSEPLE
Highest antigen sequence indentity to the following orthologs: Rat - 56%, Mouse - 54%.
Target Information
RANK is a member of the tumor necrosis factor receptor (TNFR) family. The full length mouse RANK cDNA encodes a type I transmembrane protein with an extracellular and a cytoplasmic domain. The extracellular domain contains two potential N-linked glycosylation sites. RANK shares significant amino acid homology with other members of the TNFR family in its extracellular four cysteine-rich repeats. Human and murine RANK share 81% amino acid identity in their extracellular domains.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CD265; familial expansile osteolysis; loss of heterozygosity, 18, chromosomal region 1; ODFR; Osteoclast differentiation factor receptor; Paget disease of bone 2; Receptor activator of NF-KB; receptor activator of nuclear factor-kappa B; TRANCE receptor; Tumor necrosis factor receptor superfamily member 11A; tumor necrosis factor receptor superfamily, member 11a, NFKB activator
Gene Aliases: CD265; FEO; LOH18CR1; ODFR; OFE; OPTB7; OSTS; PDB2; RANK; TNFRSF11A; TRANCE-R; TRANCER
UniProt ID: (Human) Q9Y6Q6
Entrez Gene ID: (Human) 8792
ossification
adaptive immune response
immune system process
monocyte chemotaxis
signal transduction
cell-cell signaling
positive regulation of cell proliferation
response to mechanical stimulus
osteoclast differentiation
response to lipopolysaccharide
response to insulin
tumor necrosis factor-mediated signaling pathway
cellular response to zinc ion starvation
response to tumor necrosis factor
positive regulation of I-kappaB kinase/NF-kappaB signaling
response to ethanol
positive regulation of osteoclast differentiation
positive regulation of bone resorption
positive regulation of JNK cascade
lymph node development
circadian temperature homeostasis
mammary gland alveolus development
positive regulation of ERK1 and ERK2 cascade
response to interleukin-1
positive regulation of fever generation by positive regulation of prostaglandin secretion
multinuclear osteoclast differentiation
positive regulation of NIK/NF-kappaB signaling
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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