Search
Invitrogen
TGM2 Polyclonal Antibody
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}
Additional Information:
{{banner.description}}
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-110980
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant Protein corresonding to Human TGM2. Recombinant protein control fragment (Product #RP-92583).
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
0.10 mg/mL
Amount
10 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: VEPVINSYLL AERDLYLENP EIKIRILGEP KQKRKLVAEV SLQNPLPVAL EGCTFTVEGA GLTEEQKTVE IPDPVEAGEE VKVRMDLLP
Highest antigen sequence indentity to the following orthologs: Mouse - 75%, Rat - 79%.
Target Information
Transglutaminase (TGase) catalyses the crosslink of proteins by forming e-(g-glutamyl) lysine isopeptide bonds and requires the binding of Ca2+ for its activity. In mammals, eight distinct TGase isoenzymes have been identified. Tissue transglutaminase (tTGase), also known as TGase 2, has four distinct domains: N-terminal b-sandwich, catalytic core and two C-terminal b-barrel domains. tTGase may have a role in cell death, cell proliferation, cell differentiation, and receptor-mediated endocytosis. In the Alzheimer's disease brain, the elevated tTGase activity is manifested by polymerization of a number of proteins, including Ab peptide, b-amyloid precursor protein and the tau protein, with formation of neurofibrillary tangles.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Have you cited this product in a publication?
Let us know so we can reference it here.
Bioinformatics
Protein Aliases: C polypeptide, protein-glutamine-gamma-glutamyltransferase; crosslinker; erythrocyte transglutaminase; G alpha h; G-ALPHA-h; GNAH; heart G alpha(h); hhG alpha(h); isopeptidase TGM2; protein G alpha(h); protein-glutamine deamidase TGM2; protein-glutamine dopaminyltransferase TGM2; protein-glutamine histaminyltransferase TGM2; protein-glutamine noradrenalinyltransferase TGM2; protein-glutamine serotonyltransferase TGM2; RP5-1054A22.2; TGase C; TGase H; TGase II; TGase-2; TGase-H; tissue transglutaminase; Tissue type transglutaminase; Transglutaminase 2 C polypeptide; transglutaminase C; transglutaminase H; transglutaminase II; tTgase; unnamed protein product
Gene Aliases: G(h); hTG2; TG(C); TGC; tTG
UniProt ID: (Human) P21980
Entrez Gene ID: (Human) 7052
protein-glutamine gamma-glutamyltransferase activity
GTPase activator activity
calcium ion binding
protein binding
GTP binding
protein-glutamine glutaminase activity
peptide serotonyltransferase activity
histone serotonyltransferase activity
peptide dopaminyltransferase activity
histone dopaminyltransferase activity
peptide noradrenalinyltransferase activity
peptide histaminyltransferase activity
chromatin remodeling
phospholipase C-activating G-protein coupled receptor signaling pathway
peptide cross-linking
extracellular matrix organization
negative regulation of endoplasmic reticulum calcium ion concentration
regulation of apoptotic process
positive regulation of apoptotic process
apoptotic cell clearance
positive regulation of cell adhesion
positive regulation of neurogenesis
positive regulation of small GTPase mediated signal transduction
protein homooligomerization
positive regulation of mitochondrial calcium ion concentration
bone development
cellular response to cocaine
cellular response to dopamine
positive regulation of sprouting angiogenesis
cellular response to serotonin
regulation of apoptotic cell clearance
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support