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Invitrogen

CD40 Polyclonal Antibody

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CD40 Polyclonal Antibody

Product Details

PA5-111024

Applications
Tested Dilution
Publications

Immunohistochemistry (Paraffin) (IHC (P))

1:200-1:500
-
Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant Protein corresonding to Human CD40. Recombinant protein control fragment (Product #RP-95264).
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.10 mg/mL

Amount

10 µg

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.2, with 40% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2856435

Product Specific Information

Immunogen sequence: KQYLINSQCC SLCQPGQKLV SDCTEFTETE CLPCGESEFL DTWNRETHCH QHKYCDPNLG LRVQQKGTSE TDTICTCE

Highest antigen sequence indentity to the following orthologs: Mouse - 58%, Rat - 54%.

Target Information

CD40 is a single-chain glycoprotein and a member of the tumor necrosis factor receptor (TNFR) family, exhibiting significant homology to the Hodgkin's disease-associated antigen, CD30. It is expressed by B lymphocytes, follicular dendritic cells, thymic epithelium, and a subset of peripheral T cells, as well as some epithelial cells, carcinomas, and lymphoid dendritic cells. Notably, CD40 is present on all B cells except plasma cells. CD40 plays a crucial role in regulating B cell development and maturation, inducing immunoglobulin isotype-switching, and protecting B cells from surface Ig-induced apoptosis when combined with other signals such as IL-4. It promotes proliferation and is essential for T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. The interaction between CD40 and its ligand CD154 (gp39) on T cells is vital for T-B cell crosstalk, costimulation, and immune regulation. Adaptor protein TNFR2 interacts with CD40, mediating signal transduction, while the AT-hook transcription factor AKNA is reported to regulate CD40 expression, which may be important for homotypic cell interactions. Additionally, the interaction between CD40 and its ligand is necessary for amyloid-beta-induced microglial activation, suggesting a role in the early pathogenesis of Alzheimer's disease. Two alternatively spliced transcript variants encoding distinct isoforms of CD40 have been identified. Diseases associated with CD40 dysfunction include Type 3 Hyper-IgM immunodeficiency and CD40 ligand deficiency, highlighting its importance in immune and inflammatory responses.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: B cell surface antigen CD40; B cell-associated molecule; B-cell surface antigen CD40; Bp50; CD antigen CD40; CD40; CD40 molecule, TNF receptor superfamily member 5; CD40L receptor; CDw40; Immunoglobulin M; ImmunoglobulinM; MGC9013; sCD40; soluble CD40; Tumor necrosis factor receptor superfamily member 5

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Gene Aliases: Bp50; CD40; CDW40; p50; TNFRSF5

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UniProt ID: (Human) P25942

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Entrez Gene ID: (Human) 958

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Function(s)
antigen binding protein binding enzyme binding protein domain specific binding ubiquitin protein ligase binding signaling receptor activity
Process(es)
immune system process regulation of immunoglobulin production immune response-regulating cell surface receptor signaling pathway cellular calcium ion homeostasis defense response inflammatory response JAK-STAT cascade response to bacterium regulation of gene expression positive regulation of macromolecule biosynthetic process B cell mediated immunity CD40 signaling pathway platelet activation positive regulation of B cell proliferation response to nutrient levels positive regulation of interleukin-12 production response to cobalamin response to interferon-gamma cellular response to erythropoietin B cell proliferation B cell activation defense response to protozoan positive regulation of I-kappaB kinase/NF-kappaB signaling positive regulation of MAPK cascade protein kinase B signaling positive regulation of blood vessel endothelial cell migration positive regulation of angiogenesis positive regulation of nucleobase-containing compound metabolic process positive regulation of transcription from RNA polymerase II promoter positive regulation of isotype switching to IgG isotypes regulation of immune response positive regulation of developmental process positive regulation of multicellular organismal process defense response to virus protein-containing complex assembly cellular response to lipopolysaccharide cellular response to mechanical stimulus cellular response to interleukin-1 cellular response to tumor necrosis factor positive regulation of protein kinase C signaling response to peptide positive regulation of interleukin-4-mediated signaling pathway positive regulation of endothelial cell apoptotic process
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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