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Invitrogen
Coronin 3 Polyclonal Antibody
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Product Details
PA5-111141
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant Protein corresonding to Human Coronin 3. Recombinant protein control fragment (Product #RP-97664).
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: ILISLKHGYI PGKNRDLKVV KKNILDSKPT ANKKCDLISI PKKTTDTASV QNEAKLDEIL KEIKSIKDTI CNQDERISKL EQQMAKI
Highest antigen sequence indentity to the following orthologs: Mouse - 87%, Rat - 93%.
Target Information
Coronin 3 is associated with the aggression and metastasis of hepatocellular carcinoma. Coronins are a family of highly evolutionary conserved proteins reportedly involved in the regulation of actin cytoskeletal dynamics, although only coronin 3 has been shown to be related to cancer cell migration.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: coronin, actin binding protein, 1C; coronin, actin-binding protein, 1C; Coronin-1C; Coronin-3; hCRNN4
Gene Aliases: CORO1C; CRN2; CRNN4; HCRNN4
UniProt ID: (Human) Q9ULV4
Entrez Gene ID: (Human) 23603
neural crest cell migration
regulation of protein phosphorylation
negative regulation of protein phosphorylation
phagocytosis
signal transduction
regulation of epithelial cell migration
negative regulation of epithelial cell migration
regulation of fibroblast migration
actin cytoskeleton organization
negative regulation of protein kinase activity by regulation of protein phosphorylation
establishment of protein localization
regulation of focal adhesion assembly
negative regulation of focal adhesion assembly
activation of GTPase activity
regulation of substrate adhesion-dependent cell spreading
negative regulation of substrate adhesion-dependent cell spreading
regulation of ruffle assembly
positive regulation of lamellipodium morphogenesis
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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