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Invitrogen
ARTS1 Polyclonal Antibody
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Product Details
PA5-111151
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant Protein corresonding to Human ARTS1. Recombinant protein control fragment (Product #RP-104752).
Conjugate
Form
Liquid
Concentration
0.3 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: FQLVSIGKLS IEKALDLSLY LKHETEIMPV FQGLNELIPM YKLMEKRDMN EVETQFKAFL IRLLRDLIDK QTWTDEGSVS ERMLRSQLLL LACVHNYQPC VQRAEGYFRK WKESNGNLS
Highest antigen sequence indentity to the following orthologs: Mouse - 87%, Rat - 88%.
Target Information
The endoplasmic reticulum (ER) aminopeptidase 1 (ERAP1) is a 120 kDa protein localized to the lumen of the ER, which removes NH2-terminal residues from many antigenic precursors for MHC class I peptide presentation. Peptides that are presented by MHC class I on the surface of a cell must be 8-11 residues long, and ERAP1 specifically trims peptides of 9 amino acids or more. ERAP1 is also induced by interferon- gamma. The gene encoding human ERAP1 maps to chromosome 5q15. ERAP1 has previously been characterized as adipocyte-derived leucine aminopeptidase (A-LAP), puromycin-insensitive leucine-specific aminopeptidase (PILS-AP) and aminopeptidase regulator of TNFR1 shedding (ARTS-1). A-LAP is thought to inactivate several bioactive peptides, including angiotensin II and, subsequently, may be involved in the regulation of blood pressure. PILS-AP is described as playing a role in angiogenesis by regulating the proliferation and migration of endothelial cells, and ARTS-1 is characterized as a TNFR1 binding protein that promotes TNFR1 shedding. Further research will be necessary to fully elucidate the functions of this protein.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: A-LAP; Adipocyte-derived leucine aminopeptidase; Aminopeptidase PILS; aminopeptidase regulator of TNFR1 shedding; ARTS-1; CTD-2260A17.2; Endoplasmic reticulum aminopeptidase 1; endoplasmic reticulum aminopeptidase 1 delta-Exon-11 isoform; endoplasmic reticulum aminopeptidase 1 delta-Exon-13 isoform; endoplasmic reticulum aminopeptidase 1 delta-Exon-14 isoform; endoplasmic reticulum aminopeptidase 1 delta-Exon-15 isoform; endoplasmic reticulum aminopeptidase associated with antigen processing; PILS-AP; Puromycin-insensitive leucyl-specific aminopeptidase; Type 1 tumor necrosis factor receptor shedding aminopeptidase regulator
Gene Aliases: A-LAP; ALAP; APPILS; ARTS-1; ARTS1; ERAAP; ERAAP1; ERAP1; KIAA0525; PILS-AP; PILSAP; UNQ584/PRO1154
UniProt ID: (Human) Q9NZ08
Entrez Gene ID: (Human) 51752
angiogenesis
adaptive immune response
antigen processing and presentation of peptide antigen via MHC class I
membrane protein ectodomain proteolysis
regulation of blood pressure
response to bacterium
antigen processing and presentation of endogenous peptide antigen via MHC class I
peptide catabolic process
regulation of innate immune response
fat cell differentiation
positive regulation of angiogenesis
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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