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Invitrogen
MED10 Polyclonal Antibody
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Product Details
PA5-111163
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant Protein corresonding to Human MED10. Recombinant protein control fragment (Product #RP-100144).
Conjugate
Form
Liquid
Concentration
0.20 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: FEYIDQGRNP QLYTKECLER ALAKNEQVKG KIDTMKKFKS LLIQELSKVF PEDMAKYRSI RGEDHPPS
Highest antigen sequence indentity to the following orthologs: Mouse - 100%, Rat - 100%.
Target Information
MED10 is a component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Mediator complex subunit 10; Mediator of RNA polymerase II transcription subunit 10; Transformation-related gene 17 protein; Transformation-related gene 20 protein; TRG-17; TRG-20
Gene Aliases: L6; MED10; NUT2; TRG17; TRG20
UniProt ID: (Human) Q9BTT4
Entrez Gene ID: (Human) 84246
regulation of transcription from RNA polymerase II promoter
protein ubiquitination
positive regulation of transcription elongation from RNA polymerase II promoter
somatic stem cell population maintenance
positive regulation of transcription from RNA polymerase II promoter
RNA polymerase II transcriptional preinitiation complex assembly
positive regulation of transcription initiation from RNA polymerase II promoter
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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