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Invitrogen
ACVR1 Polyclonal Antibody
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Product Details
PA5-111233
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant Protein corresonding to Human ACVR1. Recombinant protein control fragment (Product #RP-108372).
Conjugate
Form
Liquid
Concentration
0.05 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: EKPKVNPKLY MCVCEGLSCG NEDHCEGQQC FSSLSINDGF HVYQKGCFQV YEQGKMTCKT PPSPGQAVEC CQGDWCNRNI TAQLPTKGKS FPGTQNFHLE
Highest antigen sequence indentity to the following orthologs: Mouse - 99%, Rat - 94%.
Target Information
Activin A receptor, type I (ACVR1) belongs to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. ACVR1 signals a specific transcriptional response in concert with activin type II receptors. The ACVR1 gene encodes activin A type I receptor, which signals a particular transcriptional response in concert with activin type II receptors. Mutations in ACVR1 have been linked to Fibrodysplasia Ossificans Progressiva (FOP), a rare genetic disorder characterized by the formation of bone in muscles, tendons, and other connective tissues, as well as Epicanthus.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: activin A receptor, type I; activin A receptor, type II-like kinase 2; Activin receptor type I; Activin receptor type-1; Activin receptor-like kinase 2; ACTR-I; ALK-2; hydroxyalkyl-protein kinase; Serine/threonine-protein kinase receptor R1; SKR1; TGF-B superfamily receptor type I; TSR-I; unnamed protein product
Gene Aliases: ACTRI; ACVR1; ACVR1A; ACVRLK2; ALK2; FOP; SKR1; TSRI
UniProt ID: (Human) Q04771
Entrez Gene ID: (Human) 90
nucleotide binding
protein kinase activity
protein serine/threonine kinase activity
transmembrane receptor protein serine/threonine kinase activity
transforming growth factor beta receptor activity, type I
protein binding
ATP binding
kinase activity
activin receptor activity, type I
transferase activity
peptide hormone binding
growth factor binding
protein homodimerization activity
cadherin binding
SMAD binding
metal ion binding
activin binding
transforming growth factor beta binding
BMP receptor activity
protein tyrosine kinase binding
patterning of blood vessels
osteoblast differentiation
in utero embryonic development
gastrulation with mouth forming second
mesoderm formation
neural crest cell migration
acute inflammatory response
embryonic heart tube morphogenesis
outflow tract septum morphogenesis
atrioventricular valve morphogenesis
mitral valve morphogenesis
endocardial cushion formation
endocardial cushion fusion
atrial septum primum morphogenesis
transmembrane receptor protein serine/threonine kinase signaling pathway
transforming growth factor beta receptor signaling pathway
germ cell development
determination of left/right symmetry
gastrulation
mesoderm development
heart development
dorsal/ventral pattern formation
negative regulation of signal transduction
cell differentiation
regulation of ossification
positive regulation of cell migration
positive regulation of bone mineralization
BMP signaling pathway
activin receptor signaling pathway
negative regulation of activin receptor signaling pathway
endothelial cell differentiation
positive regulation of cell differentiation
positive regulation of osteoblast differentiation
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
smooth muscle cell differentiation
positive regulation of multicellular organismal process
pharyngeal system development
positive regulation of SMAD protein import into nucleus
ventricular septum morphogenesis
epithelial tube morphogenesis
cardiac muscle cell fate commitment
endocardial cushion cell fate commitment
positive regulation of cardiac epithelial to mesenchymal transition
cellular response to growth factor stimulus
cellular response to BMP stimulus
circulatory system development
positive regulation of intracellular signal transduction
positive regulation of determination of dorsal identity
regulation of multicellular organismal development
negative regulation of G1/S transition of mitotic cell cycle
negative regulation of extrinsic apoptotic signaling pathway
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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