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Invitrogen
RANK Polyclonal Antibody
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Product Details
PA5-111264
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant Protein corresonding to Human RANK. Recombinant protein control fragment (Product #RP-106161).
Conjugate
Form
Liquid
Concentration
0.2 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: CTTTSDSVCL PCGPDEYLDS WNEEDKCLLH KVCDTGKALV AVVAGNSTTP RRCACTAGYH WSQDCECCRR NTECAPGLGA QHPLQLNKDT VCKPCLAGYF SDAFSSTDKC RPWTNCTFLG KRVEHHGTEK SDAVCSSSLP ARKPPNEPHV
Highest antigen sequence indentity to the following orthologs: Rat - 80%, Mouse - 79%.
Target Information
RANK is a member of the tumor necrosis factor receptor (TNFR) family. The full length mouse RANK cDNA encodes a type I transmembrane protein with an extracellular and a cytoplasmic domain. The extracellular domain contains two potential N-linked glycosylation sites. RANK shares significant amino acid homology with other members of the TNFR family in its extracellular four cysteine-rich repeats. Human and murine RANK share 81% amino acid identity in their extracellular domains.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CD265; loss of heterozygosity, 18, chromosomal region 1; ODFR; Osteoclast differentiation factor receptor; Paget disease of bone 2; Receptor activator of NF-KB; receptor activator of nuclear factor-kappa B; Tumor necrosis factor receptor superfamily member 11A; tumor necrosis factor receptor superfamily member 11a, NFKB activator; tumor necrosis factor receptor superfamily, member 11a, NFKB activator
Gene Aliases: CD265; FEO; LOH18CR1; ODFR; OFE; OPTB7; OSTS; PDB2; RANK; TNFRSF11A; TRANCER
UniProt ID: (Human) Q9Y6Q6
Entrez Gene ID: (Human) 8792
ossification
adaptive immune response
monocyte chemotaxis
inflammatory response
signal transduction
cell-cell signaling
positive regulation of cell proliferation
response to radiation
osteoclast differentiation
response to lipopolysaccharide
tumor necrosis factor-mediated signaling pathway
response to cytokine
response to tumor necrosis factor
regulation of apoptotic process
positive regulation of JUN kinase activity
lymph node development
positive regulation of sequence-specific DNA binding transcription factor activity
positive regulation of NF-kappaB transcription factor activity
circadian temperature homeostasis
mammary gland alveolus development
response to interleukin-1
positive regulation of fever generation by positive regulation of prostaglandin secretion
TNFSF11-mediated signaling pathway
positive regulation of ERK1 and ERK2 cascade via TNFSF11-mediated signaling
apoptotic signaling pathway
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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