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Invitrogen
CARD11 Polyclonal Antibody
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Product Details
PA5-111366
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant Protein corresonding to Human CARD11. Recombinant protein control fragment (Product #RP-101598).
Conjugate
Form
Liquid
Concentration
0.2 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: ELEEKNDEMR IEMVRREACI VNLESKLRRL SKDSNNLDQS LPRNLPVTII SQDFGDASPR TNGQEADDSS TSEESPEDSK YFLPYHP
Highest antigen sequence indentity to the following orthologs: Mouse - 91%, Rat - 29%.
Target Information
The protein encoded by this gene belongs to the membrane-associated guanylate kinase (MAGUK) family, a class of proteins that functions as molecular scaffolds for the assembly of multiprotein complexes at specialized regions of the plasma membrane. This protein is also a member of the CARD protein family, which is defined by carrying a characteristic caspase-associated recruitment domain (CARD). This protein has a domain structure similar to that of CARD14 protein. The CARD domains of both proteins have been shown to specifically interact with BCL10, a protein known to function as a positive regulator of cell apoptosis and NF-kappaB activation. When expressed in cells, this protein activated NF-kappaB and induced the phosphorylation of BCL10.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: bcl10-interacting maguk protein 3; CARD-containing MAGUK protein 1; CARD11; CARD/MAGUK family member; Carma 1; Caspase recruitment domain-containing protein 11; MAGUK; MGC133069
Gene Aliases: BENTA; BIMP3; CARD11; CARMA1; IMD11; IMD11A; PPBL
UniProt ID: (Human) Q9BXL7
Entrez Gene ID: (Human) 84433
immune system process
signal transduction
I-kappaB kinase/NF-kappaB signaling
B cell differentiation
positive regulation of B cell proliferation
T cell costimulation
positive regulation of interleukin-2 production
CD4-positive, alpha-beta T cell proliferation
TORC1 signaling
B cell proliferation
T cell activation
regulation of apoptotic process
positive regulation of I-kappaB kinase/NF-kappaB signaling
thymic T cell selection
regulation of B cell differentiation
regulation of T cell differentiation
GMP metabolic process
lymphocyte activation
GDP metabolic process
homeostasis of number of cells
regulation of immune response
positive regulation of T cell receptor signaling pathway
positive regulation of T cell activation
positive regulation of NF-kappaB transcription factor activity
protein homooligomerization
positive regulation of CD4-positive, alpha-beta T cell proliferation
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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