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Invitrogen
TGIF2 Polyclonal Antibody
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Product Details
PA5-111379
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant Protein corresonding to Human TGIF2. Recombinant protein control fragment (Product #RP-106494).
Conjugate
Form
Liquid
Concentration
0.2 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: SVLAVSVPAP TNVLSLSVCS MPLHSGQGEK PAAPFPRGEL ESPKPLVTPG STLTLLTRAE AGSPTGGLF
Highest antigen sequence indentity to the following orthologs: Mouse - 91%, Rat - 91%.
Target Information
The protein encoded by this gene is a DNA-binding homeobox protein and a transcriptional repressor, which appears to repress transcription by recruiting histone deacetylases to TGF beta-responsive genes. This gene is amplified and over-expressed in some ovarian cancers. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 1. Read-through transcription also exists between this gene and the neighboring downstream C20orf24 gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 5'-TG-3' interacting factor 2; 5'-TG-3'-interacting factor 2; Homeobox protein TGIF2; OTTHUMP00000030849; TGF(beta)-induced transcription factor 2; TGF-beta-induced transcription factor 2; TGFB-induced factor 2; TGFB-induced factor 2 (TALE family homeobox); transcription growth factor-beta-induced factor 2; unnamed protein product
Gene Aliases: TGIF2
UniProt ID: (Human) Q9GZN2
Entrez Gene ID: (Human) 60436
RNA polymerase II transcription factor activity, sequence-specific DNA binding
transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding
DNA binding
transcription factor activity, sequence-specific DNA binding
sequence-specific double-stranded DNA binding
negative regulation of transcription from RNA polymerase II promoter
regulation of transcription, DNA-templated
regulation of gastrulation
neuron differentiation
amacrine cell differentiation
nodal signaling pathway
retina development in camera-type eye
positive regulation of amacrine cell differentiation
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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