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Invitrogen
BAP1 Polyclonal Antibody
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Product Details
PA5-111420
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant Protein corresonding to Human BAP1. Recombinant protein control fragment (Product #RP-105016).
Conjugate
Form
Liquid
Concentration
0.10 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: PVTSHISKVL FGEDDSLLRV DCIRYNRAVR DLGPVISTGL LHLAEDGVLS PLALTEGGKG SSPSIRPIQG SQGSSSPVEK EVVEATDSRE KTGMV
Highest antigen sequence indentity to the following orthologs: Mouse - 87%, Rat - 89%.
Target Information
BRCA1-associated protein-1, or BAP1, interacts with the RING finger domain of BRCA1. The N-terminal 240 amino acids of the predicted 729-amino acid human protein show homology to ubiquitin C-terminal hydrolases (UCHs), thiol proteases that catalyze proteolytic processing of ubiquitin. In addition, BAP1 contains an acidic region, a highly charged C-terminal region, and 2 putative nuclear localization signals. BAP1 and BRCA1 associate in vivo and have overlapping subnuclear localization patterns. BAP1 enhances BRCA1-mediated inhibition of breast cancer cell growth. Northern blot analysis indicates that BAP1 is expressed as a 4-kb mRNA in all human tissues tested, with A 4. 8-kb transcript expressed exclusively in testis. Northern blot analysis and in situ hybridization reveal that BAP1 and BRCA1 are coexpressed during murine breast development and remodeling. The BAP1 gene has been mapped to 3p21. 3, a region of loss of heterozygosity for breast cancer as well as frequently deleted in lung carcinomas. Intragenic homozygous rearrangements and deletions of BAP1 appear in lung carcinoma cell lines. It has been postulated that BAP1 is a tumor suppressor gene that functions in the BRCA1 growth control pathway.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: BRCA1 associated protein 1; BRCA1 associated protein-1 (ubiquitin carboxy-terminal hydrolase); BRCA1-associated protein 1; Cerebral protein 6; cerebral protein-13; DKFZp686N04275; FLJ35406; FLJ37180; KIAA0272; medulloblastoma antigen; ubiquitin carboxy-terminal hydrolase L2; ubiquitin carboxyl-terminal hydrolase; Ubiquitin carboxyl-terminal hydrolase BAP1; unnamed protein product
Gene Aliases: BAP1; HUCEP-13; hucep-6; KIAA0272; KURIS; TPDS1; UBM2; UCHL2; UVM2
UniProt ID: (Human) Q92560
Entrez Gene ID: (Human) 8314
mitotic cell cycle
regulation of cell growth
in utero embryonic development
tissue homeostasis
thrombocyte differentiation
chromatin organization
proteolysis
ubiquitin-dependent protein catabolic process
cell proliferation
negative regulation of cell proliferation
gene expression
regulation of gene expression
protein deubiquitination
cell differentiation
erythrocyte differentiation
neutrophil differentiation
granulocyte differentiation
heterochromatin assembly
myeloid cell apoptotic process
monoubiquitinated protein deubiquitination
common myeloid progenitor cell proliferation
protein modification process
platelet morphogenesis
erythrocyte maturation
nucleate erythrocyte differentiation
negative regulation of transcription, DNA-templated
regulation of inflammatory response
regulation of cell cycle
hematopoietic stem cell homeostasis
macrophage homeostasis
neuron cellular homeostasis
leukocyte proliferation
protein K48-linked deubiquitination
regulation of cytokine production involved in inflammatory response
positive regulation of protein targeting to mitochondrion
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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