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Invitrogen
CEP164 Polyclonal Antibody
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Product Details
PA5-111529
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant Protein corresonding to Human CEP164. Recombinant protein control fragment (Product #RP-108458).
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: EVRSTEPVAP PEQLSEAALK AMEEAVAQVL EQDQRHLLES KQEKMQQLRE KLCQEEEEEI LRLHQQKEQS LSSLRERLQK AIEEE
Highest antigen sequence indentity to the following orthologs: Mouse - 40%, Rat - 61%.
Target Information
CEP164 was initially identified as a centrosomal protein, but other studies have indicated that it also plays a role in the formation of primary cilia, the microtubule-based sensory antennae projecting from the surface of many eukaryotic cells as well as in DNA damage response acting as a mediator protein. CEP164 interacts with both ATR and ATM, proteins that trigger a number of cellular responses including the initiation of DNA damaged-induced cell cycle checkpoints. It is phosphorylated upon replication stress, ultraviolet (UV) radiation, and ionizing radiation silencing of CEP164 significantly reduces the DNA damage-induced phosphorylation of several proteins in the DNA damage-activated signaling cascade and compromises cell survival after UV damage. At least two isoforms of CEP164 are known to exist.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: ce164; centrosomal protein 164kDa; Centrosomal protein of 164 kDa; Cep 164; Cep164
Gene Aliases: CEP164; KIAA1052; NPHP15
UniProt ID: (Human) Q9UPV0
Entrez Gene ID: (Human) 22897
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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