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Invitrogen
HES6 Polyclonal Antibody
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Product Details
PA5-111534
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant Protein corresonding to Human HES6. Recombinant protein control fragment (Product #RP-107093).
Conjugate
Form
Liquid
Concentration
0.05 mg/mL
Amount
5 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: PIPSPPGPGD DLCSDLEEAP EAELSQAPAE GPDLVPAALG SLTTAQIARS VWRPW
Highest antigen sequence indentity to the following orthologs: Mouse - 76%, Rat - 78%.
Target Information
The HES family members form a complex with TLE, the mammalian homologue of Groucho, and this interaction is mediated by the carboxy terminal WRPW motif of the HES proteins. The HES/TLE complex functions by directly binding to DNA, instead of interfering with activator proteins. Most HES family members, including HES1 and HES5, preferentially bind to the N box (CACNAG) as opposed to the E box (CANNTG). HES2 binds to both N and E box sites, while HES6 does not bind DNA. Rather, HES6 inhibits HES1 activity, thereby promoting transcription. HES1 and HES2 are expressed in a variety of adult and embryonic tissues. HES3 is expressed exclusively in cerebellar Purkinje cells, and HES5 is found solely in the nervous system. HES6 is produced in brain as well as in the limb buds of developing embryos.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: bHLH-WRPW transcription factor HES-6; bHLHb41; C-HAIRY1; Class B basic helix-loop-helix protein 41; Hairy and enhancer of split 6; Transcription cofactor HES-6; unnamed protein product
Gene Aliases: BHLHB41; bHLHc23; C-HAIRY1; HES-6; HES6
UniProt ID: (Human) Q96HZ4
Entrez Gene ID: (Human) 55502
RNA polymerase II regulatory region sequence-specific DNA binding
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding
DNA binding
transcription factor activity, sequence-specific DNA binding
protein binding
protein dimerization activity
RNA polymerase II sequence-specific DNA binding transcription factor binding
transcription regulator inhibitor activity
sequence-specific double-stranded DNA binding
negative regulation of transcription from RNA polymerase II promoter
regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
nervous system development
anterior/posterior pattern specification
cell differentiation
positive regulation of transcription from RNA polymerase II promoter
regulation of neurogenesis
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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