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Invitrogen
ENPP1 Polyclonal Antibody
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Product Details
PA5-111542
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant Protein corresonding to Human ENPP1. Recombinant protein control fragment (Product #RP-103430).
Conjugate
Form
Liquid
Concentration
0.10 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: GLKPSCAKEV KSCKGRCFER TFGNCRCDAA CVELGNCCLD YQETCIEPEH IWTC
Highest antigen sequence indentity to the following orthologs: Rat - 91%, Mouse - 91%.
Target Information
This gene is a member of the ecto-nucleotide pyrophosphatase/phosphodiesterase (ENPP) family. The encoded protein is a type II transmembrane glycoprotein comprising two identical disulfide-bonded subunits. This protein has broad specificity and cleaves a variety of substrates, including phosphodiester bonds of nucleotides and nucleotide sugars and pyrophosphate bonds of nucleotides and nucleotide sugars. This protein may function to hydrolyze nucleoside 5' triphosphates to their corresponding monophosphates and may also hydrolyze diadenosine polyphosphates. Mutations in this gene have been associated with 'idiopathic' infantile arterial calcification, ossification of the posterior longitudinal ligament of the spine (OPLL), and insulin resistance.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: alkaline phosphodiesterase 1; Alkaline phosphodiesterase I; E-NPP 1; Ectonucleotide pyrophosphatase/phosphodiesterase family member 1; HGNC:3356; Ly-41 antigen; Membrane component chromosome 6 surface marker 1; membrane component, chromosome 6, surface marker 1; NPPase; Nucleotide diphosphatase; Nucleotide pyrophosphatase; OTTHUMP00000043194; Phosphodiesterase I/nucleotide pyrophosphatase 1; plasma-cell membrane glycoprotein 1; Plasma-cell membrane glycoprotein PC-1; unnamed protein product
Gene Aliases: ARHR2; COLED; ENPP1; M6S1; NPP1; NPPS; PC-1; PC1; PCA1; PDNP1
UniProt ID: (Human) P22413
Entrez Gene ID: (Human) 5167
nucleic acid binding
3',5'-cyclic-AMP phosphodiesterase activity
exonuclease activity
phosphodiesterase I activity
nucleotide diphosphatase activity
scavenger receptor activity
insulin receptor binding
calcium ion binding
protein binding
ATP binding
zinc ion binding
hydrolase activity
phosphatase activity
polysaccharide binding
GTP diphosphatase activity
UTP diphosphatase activity
protein homodimerization activity
metal ion binding
nucleoside-triphosphate diphosphatase activity
ATP diphosphatase activity
3'-phosphoadenosine 5'-phosphosulfate binding
cyclic-GMP-AMP hydrolase activity
generation of precursor metabolites and energy
phosphate-containing compound metabolic process
immune response
nucleoside triphosphate catabolic process
gene expression
vesicle-mediated transport
bone mineralization
negative regulation of cell growth
melanocyte differentiation
regulation of bone mineralization
negative regulation of bone mineralization
inorganic diphosphate transport
cellular phosphate ion homeostasis
biomineral tissue development
cellular response to insulin stimulus
response to ATP
negative regulation of fat cell differentiation
negative regulation of glycogen biosynthetic process
ATP metabolic process
negative regulation of glucose import
negative regulation of insulin receptor signaling pathway
animal organ development
3'-phosphoadenosine 5'-phosphosulfate metabolic process
phosphate ion homeostasis
nucleic acid metabolic process
negative regulation of hh target transcription factor activity
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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