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Invitrogen
GP6 Polyclonal Antibody
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Product Details
PA5-111615
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant Protein corresonding to Human GP6. Recombinant protein control fragment (Product #RP-103633).
Conjugate
Form
Liquid
Concentration
0.2 mg/mL
Amount
20 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: VTLRCQGPPG VDLYRLEKLS SSRYQDQAVL FIPAMKRSLA GRYRCSYQNG SLWSLPSDQL
Highest antigen sequence indentity to the following orthologs: Mouse - 78%, Rat - 65%.
Target Information
Glycoprotein VI (GP6) is a 58-kD platelet membrane glycoprotein that plays a crucial role in the collagen-induced activation and aggregation of platelets. Upon injury to the vessel wall and subsequent damage to the endothelial lining, exposure of the subendothelial matrix to blood flow results in deposition of platelets. Collagen fibers are the most thrombogenic macromolecular components of the extracellular matrix, with collagen types I, III, and VI being the major forms found in blood vessels. Platelet interaction with collagen occurs as a 2-step procedure: (1) the initial adhesion to collagen is followed by (2) an activation step leading to platelet secretion, recruitment of additional platelets, and aggregation. In physiologic conditions, the resulting platelet plug is the initial hemostatic event limiting blood loss. However, exposure of collagen after rupture of atherosclerotic plaques is a major stimulus of thrombus formation associated with myocardial infarction or stroke.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Glycoprotein 6; GPVI; platelet collagen receptor; Platelet glycoprotein VI
Gene Aliases: BDPLT11; GP6; GPIV; GPVI
UniProt ID: (Human) Q9HCN6
Entrez Gene ID: (Human) 51206
immune response-regulating signaling pathway
enzyme linked receptor protein signaling pathway
blood coagulation
hemostasis
platelet activation
collagen-activated tyrosine kinase receptor signaling pathway
collagen-activated signaling pathway
platelet aggregation
positive regulation of platelet aggregation
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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