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Invitrogen
NOTUM Polyclonal Antibody
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Product Details
PA5-139770
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human NOTUM. Recombinant protein control fragment (Product #RP-108745).
Conjugate
Form
Liquid
Concentration
0.05 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Gently mix before use. Optimal concentrations and conditions for each application should be determined by the user.
Immunogen sequence: ANMVFIPYCS SDVWSGASSK SEKNEYAFMG ALIIQEVVRE LLGRGLSGAK VLLLAGSSAG GTGVLLNVDR VAEQLEKLGY PAIQVRGLAD SGWFL
Highest antigen sequence indentity to the following orthologs: Rat - 93%, Mouse - 93%.
Target Information
Genetic studies in Drosophila have revealed a novel secreted antagonist for Wingless (Wg) signaling, referred to as Notum/Wingful (Wf). Wf/Notum encodes a protein of 430 amino acid residues, which is related to plant pectin acetylesterases of the a/beta-hydrolase superfamily. The main target of Notum action appears to be cell surface proteoglycans Dally and/or Dally-like (Dlp). Notum governs the extracellular Wg morphogen distribution via Dally and Dlp. Also, like some vertebrate Wnt antagonists, notum expression is activated by Wg signaling, revealing the existence of a feedback control mechanism in which Wg modifies its own gradient distribution. In vertebrate, proteoglycans related to Dally and Dlp likely play important roles in Wnt signaling which encodes a glypican that is required for Wnt-11 signaling. A single ortholog of Notum exists in the mouse and the human genome, implying that a similar regulatory mechanism may exist in vertebrates.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: [Wnt protein] O-palmitoleoyl-L-serine hydrolase; hNOTUM; notum pectinacetylesterase homolog; Palmitoleoyl-protein carboxylesterase NOTUM; protein notum homolog
Gene Aliases: hNOTUM; NOTUM; OK/SW-CL.30
UniProt ID: (Human) Q6P988
Entrez Gene ID: (Human) 147111
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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