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Invitrogen
Pleiotrophin Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-139921
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human PTN. Recombinant protein control fragment (Product #RP-109373).
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
0.05 mg/mL
Amount
5 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Gently mix before use. Optimal concentrations and conditions for each application should be determined by the user.
Immunogen sequence: KQFGAECKYQ FQAWGECDLN TALKTRTGSL KRALHNAECQ KTVTISKPCG KLTKPKPQAE SKKK
Highest antigen sequence indentity to the following orthologs: Mouse - 98%, Rat - 98%.
Target Information
Pleiotrophin (PTN) is an 18 kDa secreted heparin and chondroitin-binding protein that is a regulatory cytokine critical to the early development of blood vessels and neurons. High PTN serum levels are associated with a variety of solid tumors. It was shown that patients with multiple myeloma (MM) also have elevated serum levels of this protein. The expression of this protein is very limited in normal adult tissues.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: heparin affin regulatory protein; heparin-binding brain mitogen; heparin-binding growth factor 8; heparin-binding growth-associated molecule; heparin-binding neurite outgrowth promoting factor; heparin-binding neurite outgrowth-promoting factor 1; osf-1; osteoblast-specific factor 1; pleiotrophin (heparin binding growth factor 8, neurite growth-promoting factor 1); PTN; unnamed protein product
Gene Aliases: HARP; HB-GAM; HBBM; HBGF-8; HBGF8; HBNF; HBNF-1; NEGF1; OSF-1
UniProt ID: (Human) P21246
Entrez Gene ID: (Human) 5764
leukocyte chemotaxis involved in inflammatory response
positive regulation of leukocyte chemotaxis
transmembrane receptor protein tyrosine phosphatase signaling pathway
integrin-mediated signaling pathway
nervous system development
negative regulation of neuroblast proliferation
learning
memory
positive regulation of cell proliferation
regulation of endothelial cell migration
positive regulation of neuron projection development
response to auditory stimulus
positive regulation of bone mineralization
dendrite regeneration
regulation of myelination
tissue regeneration
receptor clustering
ossification involved in bone remodeling
estrous cycle
positive regulation of cell differentiation
positive regulation of ossification
decidualization
regulation of synaptic plasticity
oogenesis
positive regulation of axon regeneration
positive regulation of oligodendrocyte differentiation
modulation of synaptic transmission
dendrite arborization
positive regulation of dendrite development
negative regulation of long-term synaptic potentiation
regulation of hemopoiesis
regulation of stem cell population maintenance
positive regulation of hepatocyte proliferation
positive regulation of stem cell differentiation
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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