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Invitrogen
Pleiotrophin Polyclonal Antibody
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Product Details
PA5-139921
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human PTN. Recombinant protein control fragment (Product #RP-109373).
Conjugate
Form
Liquid
Concentration
0.05 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Gently mix before use. Optimal concentrations and conditions for each application should be determined by the user.
Immunogen sequence: KQFGAECKYQ FQAWGECDLN TALKTRTGSL KRALHNAECQ KTVTISKPCG KLTKPKPQAE SKKK
Highest antigen sequence indentity to the following orthologs: Mouse - 98%, Rat - 98%.
Target Information
Pleiotrophin (PTN) is an 18 kDa secreted heparin and chondroitin-binding protein that is a regulatory cytokine critical to the early development of blood vessels and neurons. High PTN serum levels are associated with a variety of solid tumors. It was shown that patients with multiple myeloma (MM) also have elevated serum levels of this protein. The expression of this protein is very limited in normal adult tissues.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: HB-GAM; HBBM; HBGF-8; HBNF; HBNF-1; heparin affin regulatory protein; Heparin-binding brain mitogen; Heparin-binding growth factor 8; Heparin-binding growth-associated molecule; heparin-binding neurite outgrowth promoting factor; Heparin-binding neurite outgrowth-promoting factor; Heparin-binding neurite outgrowth-promoting factor 1; OSF-1; Osteoblast-specific factor 1; Pleiotrophin; pleiotrophin (heparin binding growth factor 8, neurite growth-promoting factor 1); PTN
Gene Aliases: HARP; HB-GAM; HBBM; HBGF-8; HBGF8; HBNF; HBNF-1; HBNF1; NEGF1; OSF-1; PTN
UniProt ID: (Human) P21246
Entrez Gene ID: (Human) 5764
liver development
transmembrane receptor protein tyrosine phosphatase signaling pathway
nervous system development
heart development
learning
positive regulation of cell proliferation
regulation of cell shape
positive regulation of cell-substrate adhesion
positive regulation of neuron projection development
response to activity
negative regulation of angiogenesis
spinal cord development
cerebellum development
thalamus development
bone mineralization
lung development
negative regulation of cell migration
response to estradiol
response to progesterone
cellular response to UV
cellular response to platelet-derived growth factor stimulus
response to drug
positive regulation of apoptotic process
negative regulation of catalytic activity
estrous cycle
endothelial cell differentiation
negative regulation of membrane potential
negative regulation of epithelial cell proliferation
positive regulation of cell division
retinal rod cell differentiation
negative regulation of glial cell proliferation
long-term synaptic potentiation
cellular response to vitamin D
cellular response to hypoxia
negative regulation of mesenchymal cell proliferation
response to kainic acid
rod bipolar cell differentiation
response to ciliary neurotrophic factor
positive regulation of skeletal muscle acetylcholine-gated channel clustering
negative regulation of neuromuscular junction development
response to nerve growth factor
positive regulation of hepatocyte proliferation
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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